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Diffusion of Molecular Diagnostic Lung Cancer Tests: A Survey of German Oncologists

机译：分子诊断性肺癌检测方法的扩散：德国肿瘤学家的调查

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This study was aimed at examining the diffusion of diagnostic lung cancer tests in Germany. It was motivated by the high potential of detecting and targeting oncogenic drivers. Recognizing that the diffusion of diagnostic tests is a conditio sine qua non for the success of personalized lung cancer therapies, this study analyzed the diffusion of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tests in Germany. Qualitative and quantitative research strategies were combined in a mixed-method design. A literature review and subsequent Key Opinion Leader interviews identified a set of qualitative factors driving the diffusion process, which were then translated into an online survey. The survey was conducted among a sample of 961 oncologists (11.34% response rate). The responses were analyzed in a multiple linear regression which identified six statistically significant factors driving the diffusion of molecular diagnostic lung cancer tests: reimbursement, attitude towards R&D, information self-assessment, perceived attitudes of colleagues, age and test-pathway strategies. Besides the important role of adequate reimbursement and relevant guidelines, the results of this study suggest that an increasing usage of test-pathway strategies, especially in an office-based setting, can increase the diffusion of molecular diagnostic lung cancer tests in the future.
机译：这项研究旨在检查德国诊断性肺癌检测方法的普及情况。它被发现和靶向致癌驱动程序的巨大潜力所激发。认识到诊断测试的扩散是个性化肺癌治疗成功的先决条件，因此本研究分析了德国的表皮生长因子受体（EGFR）和间变性淋巴瘤激酶（ALK）测试的扩散。定性和定量研究策略在混合方法设计中结合在一起。文献综述和随后的关键意见领袖访谈确定了驱动扩散过程的一系列定性因素，然后将其转化为在线调查。该调查是在961名肿瘤科医生的样本中进行的（答复率为11.34％）。在多元线性回归分析中对这些反应进行了分析，该线性回归确定了六个统计学上显着的因素推动了分子诊断性肺癌测试的扩散：报销，对研发的态度，信息自我评估，同事的感知态度，年龄和测试途径策略。除了适当的报销和相关准则的重要作用外，这项研究的结果表明，越来越多地使用测试途径策略，尤其是在办公室环境中，将来可能会增加分子诊断性肺癌测试的扩散。

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