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首页> 外文期刊>Journal of Personalized Medicine >Genetic Variations in Sweet Taste Receptor Gene Are Related to Chocolate Powder and Dietary Fiber Intake in Obese Children and Adolescents
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Genetic Variations in Sweet Taste Receptor Gene Are Related to Chocolate Powder and Dietary Fiber Intake in Obese Children and Adolescents

机译：肥胖儿童和青少年甜味受体基因的遗传变异与巧克力粉和膳食纤维摄入量有关

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Childhood obesity is a major public health problem. It has a direct impact on the quality of life of children and adolescents, as well as on their future risk of developing chronic diseases. Dietary patterns rich in fats and sugars and lacking dietary fibers, vitamins, and minerals, as well as lack of physical exercise have been associated with the rise of obesity prevalence. However, factors that contribute to the preference for foods rich in these nutrients are not well established. Taste is recognized as an important predictor of food choices, and polymorphisms in taste-related genes may explain the variability of taste preference and food intake. The aim of this research is to evaluate the influence of polymorphisms of the sweet taste receptor gene TAS1R2 on diet and metabolic profile in obese children and adolescents. A cross-sectional study with 513 obese children and adolescents and 135 normal-weight children was carried out. A molecular study was performed for the single nucleotide polymorphisms (SNPs) rs9701796 and rs35874116 of TAS1R2 , and dietary intake, anthropometric parameters (weight, height, waist circumference, waist-to-height ratio (WHtR)), and metabolic profile (including fasting glucose, insulin, triglyceride, high-density lipoprotein (HDL)–cholesterol, and leptin levels) were analyzed. The variant rs9701796 was associated with increased waist-height ratio, as well as with a higher chocolate powder intake in obese children. The variant rs35874116 was associated with a lower dietary fiber intake. In conclusion, there was no relationship between genotypes and risk of obesity. Obese adolescents carrying the serine allele of SNP rs9701796 in TAS1R2 showed higher waist-to-height ratio and chocolate powder intake, whereas those carrying the valine allele of SNP rs35874116 in TAS1R2 were characterized by lower dietary fiber intake.
机译：儿童肥胖是主要的公共卫生问题。它直接影响儿童和青少年的生活质量，以及他们未来患慢性病的风险。富含脂肪和糖，缺乏膳食纤维，维生素和矿物质的饮食方式以及缺乏体育锻炼已与肥胖症患病率上升相关。但是，尚不清楚导致偏爱富含这些营养素的食物的因素。口味被认为是食物选择的重要预测指标，与口味相关的基因多态性可以解释口味偏好和食物摄入量的差异。这项研究的目的是评估甜味受体基因TAS1R2的多态性对肥胖儿童和青少年饮食和代谢状况的影响。对513名肥胖儿童和青少年以及135名体重正常的儿童进行了横断面研究。对TAS1R2的单核苷酸多态性（SNP）rs9701796和rs35874116以及饮食摄入，人体测量学参数（体重，身高，腰围，腰围与身高比（WHtR））和代谢状况（包括禁食）进行了分子研究分析了葡萄糖，胰岛素，甘油三酸酯，高密度脂蛋白（HDL）-胆固醇和瘦素的水平。变型rs9701796与肥胖儿童的腰高比增加以及巧克力粉摄入量增加有关。变体rs35874116与较低的膳食纤维摄入量相关。总之，基因型与肥胖风险之间没有关系。在TAS1R2中携带SNP rs9701796丝氨酸等位基因的肥胖青少年腰围身高比和巧克力粉摄入量较高，而在TAS1R2中携带SNP rs35874116缬氨酸等位基因的肥胖青少年的特征是膳食纤维摄入量较低。

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