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首页> 外文期刊>Journal of Pharmacology and Pharmacotherapeutics >Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients
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Adverse drug reactions of nonsteroidal anti-inflammatory drugs in orthopedic patients

机译:骨科患者非甾体类抗炎药的药物不良反应

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Objectives:To identify the ADRs due to NSAIDs and to know how to monitor the drug’s effect.Materials and Methods:A descriptive study was undertaken in the Orthopedic Outpatients Department of a tertiary care teaching hospital. Hundred patients were enrolled in this study to observe the risk of adverse drug reactions (ADRs) due to NSAIDs. All the ADRs were further analyzed in relation to age and sex, type of drug and its pattern. Probability scale was used for the causality assessment of the ADRs.Results:26% of the 100 patients developed ADR due to NSAIDs. There was not much of a difference in the number of the ADRs in relation to the gender. Diclofenac was the highest prescribed drug (65 patients), followed by paracetamol (12), nimesulide (10), ibuprofen (6), piroxicam (5) and Etoricoxib (2). Diclofenac accounted for the maximum number (73%) of ADRs, followed by nimesulide (16%), paracetamol (7%), and Etoricoxib (4%).Conclusion:Pharmacovigilance improves recognition of ADRs by the medical students. It allows the treating physician to identify the ADR associated with drugs, in particular, with the ones considered relatively safe and with those commonly prescribed by the medical and non-health professionals.
机译:目的:确定由非甾体抗炎药引起的不良反应,并了解如何监测该药的作用。材料与方法:在三级教学医院骨科门诊部进行了描述性研究。数百名患者参加了这项研究,以观察由于NSAID引起的药物不良反应(ADR)的风险。进一步分析了所有ADR与年龄和性别,药物类型及其模式有关。结果:100名患者中有26%因非甾体抗炎药而发展为ADR。 ADR的数量与性别没有太大差异。双氯芬酸是处方药最高的患者(65名患者),其次是对乙酰氨基酚(12),尼美舒利(10),布洛芬(6),吡罗昔康(5)和依托考昔(2)。双氯芬酸占ADR的最大数量(73%),其次是尼美舒利(16%),扑热息痛(7%)和依托昔布(4%)。结论:药物警戒提高了医学生对ADR的认识。它允许治疗医师识别与药物相关的ADR,尤其是与被认为相对安全的药物以及医学和非健康专业人员通常开具的药物有关的ADR。

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