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首页> 外文期刊>Journal of Rural and Remote Environmental Health >HUMAN PAPILLOMAVIRUS IN BASAL CELL CARCINOMA ?A PILOT STUDY
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HUMAN PAPILLOMAVIRUS IN BASAL CELL CARCINOMA ?A PILOT STUDY

机译：基底细胞癌中人乳头瘤病毒的初步研究

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Objectives: The study investigated whether test results for human papillomavirus (HPV) are influenced by the sampling site of the specimens. Methods: The present study was a pilot study for a large case-control study currently been conducted and included 14 immune-competent north Australian patients with histologically confirmed basal cell carcinoma. Specimens assessed were the cancer tissue, peri-lesional skin, healthy skin, and eyebrow hairs. HPV types were identified by single-tube nested 'hanging droplet' polymerase chain reaction. Results: HPV was isolated from four patients (28.6%; 95%-confidence interval = [4.0, 32.7]) with up to three of the samples from these patients testing positive for HPV. The prevalence of HPV and the types involved varied with the sampling site. All healthy skin samples were negative for HPV. Conclusions: HPV results varied considerably with the sample site in patients with basal cell carcinoma. Therefore, the authors suggest that standardising specimen collection for HPV analysis to the cancer site should reduce the possibility of detecting HPV types unrelated to the development of skin cancer.
机译：目的：该研究调查了人乳头瘤病毒（HPV）的测试结果是否受到标本采样点的影响。方法：本研究是一项针对目前进行的大型病例对照研究的试点研究，纳入了14例具有免疫功能的北澳大利亚州组织学确诊的基底细胞癌患者。评估的标本是癌组织，病灶周围皮肤，健康皮肤和眉毛。通过单管嵌套“悬滴”聚合酶链反应鉴定HPV类型。结果：从四名患者（28.6％; 95％的置信区间= [4.0，32.7]）中分离出HPV，这些患者中多达三份的HPV检测呈阳性。 HPV的患病率和涉及的类型随采样地点的不同而不同。所有健康的皮肤样本均为HPV阴性。结论：基底细胞癌患者的HPV结果随样本部位的不同而有很大差异。因此，作者建议对癌症部位进行HPV分析的标本采集标准化应减少检测与皮肤癌的发生无关的HPV类型的可能性。

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