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首页> 外文期刊>Journal of postgraduate medicine. >Serum 25 hydroxyvitamin D profile after single large oral doses of cholecalciferol (vitamin D3) in medical staff in North India: A pilot study
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Serum 25 hydroxyvitamin D profile after single large oral doses of cholecalciferol (vitamin D3) in medical staff in North India: A pilot study

机译：印度北部医务人员单次大剂量口服胆钙化醇（维生素D3）后的血清25羟维生素D分布：一项初步研究

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Background: Vitamin D deficiency is widely prevalent in India and subjects who have almost no exposure to sunlight are severely deficient. Daily oral doses of cholecalciferol (vitamin D3) are costly as compared to stoss doses and further, take a long time for the serum levels to reach a plateau. Compliance to supplementation may also be better if a regimen involves single oral doses of vitamin D at specified intervals rather than daily doses. Evidence-based guidelines regarding the dosing and the frequency of dosing for prophylactic intermittent supplementation (stoss doses) in severely-deficient subjects are few. Materials and Methods: In a prospective intervention study, we serially assessed 30 asymptomatic healthy medical staff for serum 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH); (a) at baseline; (b) monthly for 3 months after single oral 60,000 units (U) cholecalciferol; (c) monthly for 3 months after 120,000 (or 180,000 for those with elevated alkaline phosphatase) U cholecalciferol; and, (d) subsequently, at 3 months after a repeat dose of 60,000 U cholecalciferol by repeated measures analysis of variance. Results: The baseline serum 25(OH)D was 7.1 ± 5.4 ng/mL ( 10 ng/mL in 85% subjects) which increased to 18.7 ± 8.9 ng/mL at 1 month after 60,000 U of cholecalciferol (P 0.001) and decreased to 11.1 ± 5.3 ng/mL by the 3 rd month. The higher dose of 120,000 (or 180,000) U increased mean 25(OH)D to 28.9 ± 9.9 ng/mL at the end of 1 st month, declining to 17.9 ± 4.9 ng/mL (P 0.001) at 3 months. With the subsequent 60,000 U the serum 25(OH)D was 18.4 ± 3.9 ng/mL at 3 months. PTH showed a corresponding negative trend. No hypercalcemia was observed. Conclusions: Vitamin D deficiency is highly prevalent amongst medical staff in Northern India. An initial dose of 120,000-180,000 U of cholecalciferol is required to elevate 25(OH)D out of the deficiency range. Maintenance dose is needed at 2 months.
机译：背景：维生素D缺乏症在印度普遍存在，几乎没有阳光照射的受试者严重缺乏维生素D。与无用剂量相比，每日口服胆钙化醇（维生素D3）价格昂贵，而且血清水平达到平稳需要很长时间。如果某方案涉及在指定间隔内单次口服维生素D而不是每日剂量，则对补充剂的依从性也可能更好。在严重缺乏的受试者中，关于预防性间歇性补充剂量（剂量）的剂量和剂量频率的循证指南很少。材料和方法：在一项前瞻性干预研究中，我们连续评估了30名无症状健康医护人员的血清25-羟基维生素D [25（OH）D]和甲状旁腺激素（PTH）。 （a）在基线; （b）单次口服60,000单位（U）胆钙化固醇后，每月3个月; （c）在120,000（或碱性磷酸酶水平升高的人）U胆钙化醇后3个月每月一次; （d）随后，在重复剂量60,000 U胆钙化固醇的3个月后，通过重复测量方差分析。结果：基线血清25（OH）D为7.1±5.4 ng / mL（85％受试者中<10 ng / mL），在60,000 U胆钙化固醇后1个月增加至18.7±8.9 ng / mL（P <0.001）并在 rd 月的3个月内降至11.1±5.3 ng / mL。 120,000（或180,000）U的较高剂量在每月的1个月末将平均25（OH）D增加到28.9±9.9 ng / mL，下降到17.9±4.9 ng / mL（P < 0.001）（3个月）。随后的60,000 U在3个月时的血清25（OH）D为18.4±3.9 ng / mL。 PTH显示出相应的负趋势。没有观察到高钙血症。结论：维生素D缺乏症在印度北部的医务人员中非常普遍。需要初始剂量120,000-180,000 U胆钙化固醇以将25（OH）D升高到缺乏范围之内。 2个月需要维持剂量。

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