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首页> 外文期刊>Journal of reproduction and fertility >Effect of local heating of the rat testis on the levels in interstitial fluid of a putative paracrine regulator of the Leydig cells and its relationship to changes in Sertoli cell secretory function
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Effect of local heating of the rat testis on the levels in interstitial fluid of a putative paracrine regulator of the Leydig cells and its relationship to changes in Sertoli cell secretory function

机译：大鼠睾丸局部加热对Leydig细胞假定旁分泌调节剂间质液水平的影响及其与支持细胞分泌功能变化的关系

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Summary. Rat testes were exposed to heat (43°C) for 15 or 30 min to induce moderate or severe disruption of spermatogenesis, respectively. Over 3–42 days after treatment, testicular morphology and weight, the serum concentrations of FSH and the concentrations in interstitial fluid of testosterone, androgen-binding protein (ABP) and a factor(s) capable of stimulating Leydig cell testosterone secretion were monitored. Moderate seminiferous tubule damage induced by 15 min heat exposure caused a small decrease (20%) in testicular weight, but did not affect the other measures, other than transiently. In contrast, after exposure of testes to heat for 30 min there was a major and progressive decline in testicular weight throughout the experimental period, reaching 39% of control values by 42 days. In these animals, the serum concentrations of FSH were significantly increased (P < 0·01) throughout the period of study as also where the serum and interstitial fluid concentrations ABP (P < 0·05–0·01) and levels of interstitial fluid factor (P < 0·01).
机译：概要。将大鼠睾丸暴露于热（43°C）下15分钟或30分钟，分别诱导中度或重度精子发生中断。治疗后3-42天，监测睾丸形态和重量，血清FSH浓度，睾丸间质液中睾丸激素，雄激素结合蛋白（ABP）的浓度以及能够刺激Leydig细胞睾丸激素分泌的因子。 15分钟的热暴露引起的中度曲细精管损伤导致睾丸重量轻度下降（20％），但除了暂时性影响外，没有影响其他措施。相反，在将睾丸暴露于热下30分钟后，整个实验期间睾丸重量出现了显着的逐渐下降，到42天时达到了对照组的39％。在这些动物中，整个研究期间FSH的血清浓度均显着增加（P <0·01），血清和间质液的ABP浓度（P <0·05-0.01）和间质液的水平也明显升高系数（P <0·01）。

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