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首页> 外文期刊>Journal of Sports Medicine >Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke
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Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke

机译：运动性中暑中肠道菌群，内毒素血症，免疫功能和饮食的相互作用

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Exertional heatstroke (EHS) is a medical emergency that cannot be predicted, requires immediate whole-body cooling to reduce elevated internal body temperature, and is influenced by numerous host and environmental factors. Widely accepted predisposing factors (PDF) include prolonged or intense exercise, lack of heat acclimatization, sleep deprivation, dehydration, diet, alcohol abuse, drug use, chronic inflammation, febrile illness, older age, and nonsteroidal anti-inflammatory drug use. The present review links these factors to the human intestinal microbiota (IM) and diet, which previously have not been appreciated as PDF. This review also describes plausible mechanisms by which these PDF lead to EHS endotoxemia resulting from elevated plasma lipopolysaccharide (i.e., a structural component of the outer membrane of Gram-negative bacteria) and tissue injury from oxygen free radicals. We propose that recognizing the lifestyle and host factors which are influenced by intestine-microbial interactions, and modifying habitual dietary patterns to alter the IM ecosystem, will encourage efficient immune function, optimize the intestinal epithelial barrier, and reduce EHS morbidity and mortality.
机译：过度中暑（EHS）是一种无法预测的医疗紧急情况，需要立即进行全身冷却以降低体内温度升高，并受到许多宿主和环境因素的影响。广泛接受的诱发因素（PDF）包括长时间或剧烈运动，缺乏热适应能力，睡眠剥夺，脱水，饮食，酗酒，吸毒，慢性炎症，发热性疾病，老年人和非甾体抗炎药的使用。本综述将这些因素与人类肠道菌群（IM）和饮食联系起来，而以前人们尚未将其视为PDF。这篇综述还描述了可能的机制，这些PDF导致血浆脂多糖（即革兰氏阴性细菌外膜的结构成分）升高和氧自由基对组织的伤害导致EHS内毒素血症。我们建议，认识到受肠道-微生物相互作用影响的生活方式和宿主因素，并改变习惯饮食模式以改变IM生态系统，将鼓励有效的免疫功能，优化肠道上皮屏障，并降低EHS发病率和死亡率。

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