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首页> 外文期刊>Journal of the American Society of Nephrology: JASN >Racial Differences in the Prevalence of Chronic Kidney Disease among Participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort Study
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Racial Differences in the Prevalence of Chronic Kidney Disease among Participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort Study

机译：卒中地理和种族差异的原因（REGARDS）队列研究中参与者慢性肾脏病患病率的种族差异

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The racial disparity in the incidence of ESRD exemplified by the three- to four-fold excess risk among black compared with white individuals in the United States is not reflected in the prevalence of less severe degrees of impaired kidney function among black compared with white individuals. The four-variable Modification of Diet in Renal Disease study equation was used to evaluate the black-to-white prevalence of impaired kidney function with increasing severity of impairment among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a nationally representative, population-based cohort of individuals who are 45 yr and older. An estimated GFR (eGFR) 60 ml/min per 1.73 m2 was present in 43.3% of the 20,667 REGARDS participants and was slightly less prevalent among black than white patients (33.7 versus 49.9%; prevalence odds ratio 0.51; 95% confidence interval [CI] 0.48 to 0.54). The lower prevalence among black patients was not uniform as eGFR declined. After controlling for other patient characteristics, the black-to-white odds ratio was 0.42 (95% CI 0.40 to 0.46) at an eGFR of 50 to 59 ml/min per 1.73 m2 and increased to 1.73 (95% CI 1.02 to 2.94) at an eGFR of 10 to 19 ml/min per 1.73 m2. The disparity in prevalence of impaired kidney function among white compared with black patients reversed as the severity of impaired kidney function increased. Factors that are responsible for the increasing prevalence of severely impaired kidney function among black patients remain to be determined.
机译：在美国，黑人与白人相比，ESRD发生率的种族差异以黑人比白人高3至4倍的风险为例，但并未反映出肾功能受损程度较轻的普遍性。在中风的地理和种族差异原因（REGARDS）研究中，使用肾脏疾病饮食中的四变量修改研究方程式来评估参与者肾功能受损的黑白患病率，以及受损程度的增加。全国性的，以人口为基础的年龄在45岁以上的人群。在20,667名REGARDS受试者中，估计的GFR（eGFR）<60 ml / min / 1.73 m2，占43.3％，在黑人中患病率略低于白人（33.7对49.9％;患病几率比0.51; 95％置信区间[ CI] 0.48至0.54）。由于eGFR下降，黑人患者中较低的患病率并不一致。在控制了其他患者特征后，每1.73平方米的eGFR为50至59 ml / min时，黑白比值比为0.42（95％CI为0.40至0.46），并增加到1.73（95％CI为1.02至2.94）。每1.73平方米的eGFR为10到19毫升/分钟。随着肾脏功能受损严重程度的增加，白人与黑人患者的肾脏功能受损患病率之间的差异得到扭转。导致黑人患者肾功能严重受损患病率增加的因素仍有待确定。

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