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首页> 外文期刊>Journal of the Brazilian Chemical Society >Synthesis, Physicochemical and Photophysical Characterization of 4-(1-Pyrenyl)-butyl-α-D-mannopyranoside
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Synthesis, Physicochemical and Photophysical Characterization of 4-(1-Pyrenyl)-butyl-α-D-mannopyranoside

机译：4-（1-吡啶基）-丁基-α-D-甘露吡喃糖苷的合成，理化和光物理特性

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>Glycolipids are biomolecules composed of a lipid chain (lipophilic) and a monosaccharide or oligosaccharide as hydrophilic group. Their chemical structure and biological role make them undoubtedly good candidates for a large and continuously growing number of biotechnological applications. Mannose is a carbohydrate present on membrane glycolipids of a wide number of pathogenic microorganisms (bacteria, fungi, protozoa, and viruses) and specifically recognized by several lectins. We synthesized a mannose derivative linked through a short methylene chain to a pyrene moiety which behaves as a surfactant, able to aggregate, and retains the photophysical properties of pyrene: showing comparable absorption and emission spectra, having lower fluorescence quantum yield and the ability to form excimer, and finally the ability to produce O2(1Δg) with high quantum yields. Thus, this novel molecule would open future applications for detection (fluorescence) or inactivation (singlet oxygen) of bacterial pathogens, viruses, tumor cells, or particular cells.
机译：糖脂是由脂链（亲脂的）和作为亲水基团的单糖或寡糖组成的生物分子。它们的化学结构和生物学作用无疑使它们成为大量且不断增长的生物技术应用的良好候选者。甘露糖是存在于多种病原微生物（细菌，真菌，原生动物和病毒）的膜糖脂上的碳水化合物，并且被几种凝集素特异性识别。我们合成了通过短亚甲基链连接到pyr部分的甘露糖衍生物，pyr部分起表面活性剂的作用，能够聚集并保留retain的光物理性质：显示可比的吸收和发射光谱，具有较低的荧光量子产率和形成能力准分子，最后产生具有高量子产率的O2（1Δg）的能力。因此，该新颖分子将为细菌病原体，病毒，肿瘤细胞或特定细胞的检测（荧光）或灭活（单氧）打开未来的应用。

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