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首页> 外文期刊>Journal of the Canadian Academy of Child and Adolescent Psychiatry >Management Recommendations for Metabolic Complications Associated with Second Generation Antipsychotic Use in Children and Youth
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Management Recommendations for Metabolic Complications Associated with Second Generation Antipsychotic Use in Children and Youth

机译：与青少年使用第二代抗精神病药有关的代谢并发症的管理建议

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Background: Second generation antipsychotics (SGAs) are commonly associated with metabolic complications. These medications are being used more frequently for the treatment of mental health disorders in children, which has stimulated the need for creating formal guidelines on monitoring their safety and effectiveness. Previous guidelines have been developed for monitoring for metabolic and neurological complications. In order to assist practitioners who perform these monitoring procedures, we have created a complementary set of treatment recommendations if abnormal measurements or results are encountered. Objective: To create evidence-based recommendations to assist in managing metabolic complications in children being treated with second generation antipsychotics. Methods: A systematic review of the literature on metabolic complications of second generation antipsychotic medications in children was conducted. Members of the consensus group evaluated the information gathered from the systematic review of the literature and used a nominal group process to come to consensus on treatment recommendations. Wherever possible, references were made to existing guidelines on the evaluation and treatment of metabolic abnormalities in children. Results: Evidence-based recommendations are presented to assist in managing metabolic complications, including weight gain, increased waist circumference, elevation in cholesterol, triglycerides and glucose, liver function tests, abnormal thyroid studies, and elevation in prolactin. Conclusion: The use of SGAs requires proper monitoring procedures. This treatment guideline provides guidance to clinicians on clinical management of metabolic complications if they occur.
机译：背景：第二代抗精神病药（SGA）通常与代谢并发症相关。这些药物越来越多地用于治疗儿童的精神疾病，这刺激了需要制定正式的指南来监测其安全性和有效性。已经开发了用于监测代谢和神经系统并发症的先前指南。为了协助执行这些监视程序的从业人员，如果遇到异常的测量结果或结果，我们创建了一套补充的治疗建议。目的：建立基于证据的建议，以帮助管理接受第二代抗精神病药治疗的儿童的代谢并发症。方法：对儿童第二代抗精神病药物代谢并发症的文献进行系统综述。共识小组成员评估了从文献系统回顾中收集的信息，并使用名义上的小组程序就治疗建议达成共识。在可能的情况下，请参考有关儿童代谢异常评估和治疗的现有指南。结果：提出了循证医学建议，以帮助管理代谢并发症，包括体重增加，腰围增加，胆固醇，甘油三酸酯和葡萄糖升高，肝功能检查，甲状腺异常研究和催乳素升高。结论：使用SGA需要正确的监视程序。该治疗指南为临床医生就代谢并发症（如果发生）的临床管理提供了指导。

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