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首页> 外文期刊>Journal of the Canadian Academy of Child and Adolescent Psychiatry >The Normal Inhibition of Associations is Impaired by Clonidine in Tourette Syndrome
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The Normal Inhibition of Associations is Impaired by Clonidine in Tourette Syndrome

机译：可乐定在抽动秽语综合征中对缔合的正常抑制受到损害。

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Objective: We examined the inhibition of stimulus-stimulus associations (formally ‘conditioned inhibition’) in Tourette syndrome (TS). Method: The present study used video game style conditioned inhibition procedures suitable for children and adolescents. We tested 15 participants with a clinical diagnosis of TS in the absence of co-morbid attention deficit hyperactivity disorder and compared them with 19 typically developing age and sex matched controls (both groups aged 10–20 years). All children were tested for inhibition by summation test using two test stimuli in each of two conditioned inhibition tasks. Results: TS participants showed overall normal inhibition of stimulus-stimulus associations, and there was no correlation between inhibitory learning scores and symptom severity ratings. However, there was a clear reduction in conditioned inhibition in 7 TS participants medicated with clonidine. There was no significant effect of medication on excitatory learning of the stimulus-stimulus associations. Conclusions: We suggest that clonidine’s effect on inhibitory as opposed to excitatory learning could be related to reduced noradrenergic activity. In terms of clinical implications for TS, impaired conditioned inhibition could reduce the ability of susceptible individuals to learn to control tics in the presence of associative triggers.
机译：目的：我们研究了对Tourette综合征（TS）的刺激与刺激关联的抑制作用（正式称为“条件抑制”）。方法：本研究使用适合儿童和青少年的视频游戏风格条件抑制程序。我们测试了15名在没有合并症的注意缺陷多动障碍的情况下临床诊断为TS的参与者，并将他们与19名典型的发育年龄和性别相匹配的对照组（两组年龄均为10至20岁）进行了比较。在两个条件性抑制任务的每一个中，使用两个测试刺激通过求和测试对所有儿童进行抑制性测试。结果：TS参与者表现出总体上正常的刺激-刺激关联抑制作用，抑制性学习评分与症状严重程度评分之间没有相关性。然而，用可乐定治疗的7名TS参与者的条件抑制作用明显降低。药物对刺激-刺激关联的兴奋性学习没有显着影响。结论：我们建议可乐定对抑制性的抑制作用与兴奋性学习相反，可能与降低的去甲肾上腺素能活性有关。就TS的临床意义而言，条件性抑制受损可能会降低易感个体在存在关联触发因素的情况下学习控制抽动的能力。

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