• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Egyptian Women s Dermatologic Society >Increased density of CD1a+ Langerhans cells and CD86+ cells in perilesional and lesional psoriatic skin: an immunohistochemical study
【24h】

Increased density of CD1a+ Langerhans cells and CD86+ cells in perilesional and lesional psoriatic skin: an immunohistochemical study

机译：皮损周围和皮损皮肤中CD1a + Langerhans细胞和CD86 +细胞密度增加：一项免疫组织化学研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

alterations of DC. Objective To characterize CD1a+ and CD86+ cells in chronic plaque psoriasis. Patients and methods Monoclonal antibodies against CD1a+ and CD86+ were used for immunohistochemical evaluation of these molecules in the lesional and perilesional skin obtained from 30 psoriatic cases. Five cases represented the control group (healthy skin). Results We found significant variations in the density of CD1a+ and CD86+ cells among the control skin compared with the perilesional and lesional psoriatic skin. There was an increased density of CD1a+ Langerhans and CD86+ DC in the perilesional and lesional psoriatic skin compared with healthy skin. Higher counts of CD1a+ Langerhans cells in the epidermis and CD86+ cells in both epidermis and dermis of the perilesional psoriatic skin were observed compared with lesional ones. Conclusion The prominent density of CD1a+ and CD86+ DC in the perilesional skin compared with the lesional psoriatic skin suggests the pathogenetic role of these cells in the initiation of plaque psoriasis. The simultaneous presence and close localization of CD1a+ and CD86+ cells in the psoriatic dermal and epidermal compartments suggests that their interaction potentially contributes to the development of psoriasis....
机译：DC的变化。目的鉴定慢性斑块状牛皮癣中的CD1a +和CD86 +细胞。患者和方法使用针对CD1a +和CD86 +的单克隆抗体，对从30例银屑病病例中获得的病灶和病灶周围皮肤中的这些分子进行免疫组织化学评估。五例为对照组（皮肤健康）。结果我们发现与皮损周围和皮损皮肤相比，对照皮肤中CD1a +和CD86 +细胞的密度存在显着差异。与健康皮肤相比，皮损周围和皮损牛皮癣皮肤中CD1a +朗格汉斯和CD86 + DC的密度增加。与病变部位相比，皮损周围牛皮癣皮肤的表皮中CD1a + Langerhans细胞和表皮及真皮中CD86 +细胞的计数更高。结论与皮损性银屑病皮肤相比，皮损性皮肤CD1a +和CD86 + DC的显着密度提示这些细胞在斑块状牛皮癣的发病中具有致病作用。银屑病真皮和表皮区室中CD1a +和CD86 +细胞的同时存在和紧密定位表明它们的相互作用潜在地促进了牛皮癣的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号