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首页> 外文期刊>Journal of Taibah University Medical Sciences >Histopathological patterns of primary malignant ovarian neoplasms in different age groups in Almadinah Almunawwarah region, KSA
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Histopathological patterns of primary malignant ovarian neoplasms in different age groups in Almadinah Almunawwarah region, KSA

机译：KSA Almadinah Almunawwarah地区不同年龄组的原发性卵巢恶性肿瘤的组织病理学模式

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ObjectivesIn the literature, the epidemiological pattern of ovarian neoplasms in different age groups in the Almadinah Almunawwarah region in KSA has not been completely elucidated. Moreover, an unusually frequent diagnosis of adult granulosa cell tumour (AGCT) has been observed in patients in Almadinah Almunawwarah, KSA. This study aimed to describe the pattern of ovarian neoplasms in different age groups in the Almadinah Almunawwarah region with particular emphasis on AGCT.MethodsHistopathological records of all ovarian specimens diagnosed from 2011 January to 2016 December were collected from the Maternity and Children Hospital in Almaadinah Almunawwarah, KSA. Hematoxylin and eosin (HE)-stained microscopic slides of serous and mucinous epithelial borderline neoplasms and of malignant epithelial, sex cord-stromal and germ line neoplasms were identified and examined. The tissue sections from the AGCT were stained immunohistochemically withBRCA-1antibody.ResultsA total of 301 ovarian specimens were obtained. Of the specimens, 217 (72%) were neoplastic and 84 (28%) were non-neoplastic. In total, 135 (63%) of the neoplastic specimens were benign, 16 (7%) were borderline tumours, and 66 (30%) were malignant tumours. Moreover, 41 (62%) of the malignant tumours were surface epithelial carcinomas, 17 (26%) were sex cord-stromal tumours, and 8 (12%) were germ cell tumours. The incidence of AGCT was unusually high, which accounts for 26% (16/66) of all malignant ovarian neoplasms. Altered BRCA-1 expression was observed in only two specimens.ConclusionIn this study, malignant ovarian neoplasms accounted for 30% of all neoplastic ovarian specimens, and the incidence of AGCT was remarkable. Such tumours did not show a significantly altered expression ofBRCA-1.Further studies must be conducted to explore the underlying molecular causes of this condition.
机译：目的在文献中，尚未完全阐明KSA Almadinah Almunawwarah地区不同年龄组的卵巢肿瘤的流行病学模式。此外，在KSA的Almadinah Almunawwarah的患者中，发现了异常频繁的成人颗粒细胞瘤（AGCT）诊断。这项研究旨在描述Almadinah Almunawwarah地区不同年龄组的卵巢肿瘤模式，特别是AGCT方法.2011年1月至2016年12月诊断的所有卵巢标本的病理组织学记录来自Almaadinah Almunawwarah妇产儿童医院， KSA。苏木精和曙红（HE）染色的浆液和粘液上皮交界性肿瘤以及恶性上皮，性索间质和种系肿瘤的显微镜载玻片被鉴定和检查。用BRCA-1抗体对AGCT的组织切片进行免疫组织化学染色，结果共获得301份卵巢标本。在标本中，有217例（72％）为肿瘤性，而84例（28％）为非肿瘤性。总共135例（63％）的肿瘤标本是良性的，16例（7％）的是边缘性肿瘤，66例（30％）是恶性肿瘤。此外，恶性肿瘤中有41例（62％）是表面上皮癌，性索间质肿瘤是17例（26％），生殖细胞瘤是8例（12％）。 AGCT的发生率异常高，占所有恶性卵巢肿瘤的26％（16/66）。仅在两个标本中观察到了BRCA-1表达的改变。结论在这项研究中，恶性卵巢肿瘤占所有肿瘤性卵巢标本的30％，AGCT的发生率显着。此类肿瘤并未显示出BRCA-1的表达发生明显变化。必须进一步研究以探讨这种情况的潜在分子原因。

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