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首页> 外文期刊>Journal of the International Society of Sports Nutrition >Effects of an amylopectin and chromium complex on the anabolic response to a suboptimal dose of whey protein
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Effects of an amylopectin and chromium complex on the anabolic response to a suboptimal dose of whey protein

机译：支链淀粉和铬配合物对次适量乳清蛋白合成代谢反应的影响

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BackgroundPrevious research has demonstrated the permissive effect of insulin on muscle protein kinetics, and the enhanced insulin sensitizing effect of chromium. In the presence of adequate whole protein and/or essential amino acids (EAA), insulin has a stimulatory effect on muscle protein synthesis, whereas in conditions of lower blood EAA concentrations, insulin has an inhibitory effect on protein breakdown. In this study, we determined the effect of an amylopectin/chromium (ACr) complex on changes in plasma concentrations of EAA, insulin, glucose, and the fractional rate of muscle protein synthesis (FSR). MethodsUsing a double-blind, cross-over design, ten subjects (six men, four women) consumed 6?g whey protein?+?2?g of the amylopectin-chromium complex (WPACr) or 6?g whey protein (WP) after an overnight fast. FSR was measured using a primed, continuous infusion of ring-d5-phenylalanine with serial muscle biopsies performed at 2, 4, and 8?h. Plasma EAA and insulin were assayed by ion-exchange chromatography and ELISA, respectively. After the biopsy at 4?h, subjects ingested their respective supplement, completed eight sets of bilateral isotonic leg extensions at 80% of their estimated 1-RM, and a final biopsy was obtained 4?h later. ResultsBoth trials increased EAA similarly, with peak levels noted 30?min after ingestion. Insulin tended ( p =?0.09) to be higher in the WPACr trial. Paired samples t-tests using baseline and 4-h post-ingestion FSR data separately for each group revealed significant increases in the WPACr group (+0.0197%/h, p =?0.0004) and no difference in the WP group (+0.01215%/hr, p =?0.23). Independent t-tests confirmed significant ( p =?0.045) differences in post-treatment FSR between trials. ConclusionsThese data indicate that the addition of ACr to a 6?g dose of whey protein (WPACr) increases the FSR response beyond what is seen with a suboptimal dose of whey protein alone.
机译：背景先前的研究证明了胰岛素对肌肉蛋白质动力学的允许作用以及铬对胰岛素的增敏作用。在存在足够的全蛋白和/或必需氨基酸（EAA）的情况下，胰岛素对肌肉蛋白质合成具有刺激作用，而在血液EAA浓度较低的情况下，胰岛素对蛋白质分解具有抑制作用。在这项研究中，我们确定了支链淀粉/铬（ACr）复合物对血浆EAA，胰岛素，葡萄糖浓度和肌肉蛋白质合成（FSR）分数变化的影响。方法采用双盲，交叉设计，十名受试者（六名男性，四名女性）消耗了6微克乳清蛋白+2微克支链淀粉-铬复合物（WPACr）或6微克乳清蛋白（WP）。一夜之间禁食后。 FSR的测定是通过在第2、4和8小时对环d 5 -苯丙氨酸进行灌注，连续输注并进行连续肌肉活检来进行的。血浆EAA和胰岛素分别通过离子交换色谱法和ELISA法测定。在4？h进行活检后，受试者摄入各自的补充剂，以其估计的1-RM的80％完成八组双侧等张腿伸直，并在4？h后获得最终的活检。结果两项试验均相似地增加了EAA，在摄入后30分钟达到峰值水平。在WPACr试验中，胰岛素倾向于升高（p =？0.09）。每组分别使用基线和摄取后4小时FSR数据的配对样本t检验显示，WPACr组显着增加（+ 0.0197％/ h，p =？0.0004），而WP组无差异（+ 0.01215％） /hr，p＝0.23）。独立的t检验证实了试验之间治疗后FSR的显着差异（p =？0.045）。结论这些数据表明，在6微克剂量的乳清蛋白（WPACr）中添加ACr可以提高FSR响应，超出仅次优剂量的乳清蛋白所见不到的情况。

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