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首页> 外文期刊>Journal of Young Pharmacists >Antioxidant, Antinociceptive and Anti-inflammatory Activities of Ethanolic Extract of Leaves of Alocasia indica (Schott.)
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Antioxidant, Antinociceptive and Anti-inflammatory Activities of Ethanolic Extract of Leaves of Alocasia indica (Schott.)

机译：海芋叶片乙醇提取物的抗氧化，抗伤害感受和消炎作用

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摘要

Extracts obtained from the leaves of various Alocasia species have been used in India as folk remedy for the treatment of various inflammatory ailments including rheumatism and bruise. The ethanolic extract of leaves of Alocasia indica Schott. was evaluated by using different in vitro antioxidant models of screening like scavenging of 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical, nitric oxide radical, superoxide anion radical, and hydroxyl radical. The antinociceptive activity was tested by acetic acid-induced writhing response, hot plate method, and tail flick method in albino rats. The anti-inflammatory potential of gels of ethanolic extract has been determined by using carrageenan-induced paw edema assay, formalin-induced paw edema assay, arachidonic acid-induced ear edema assay, and xylene-induced ear edema assay. The extract showed remarkable antioxidant activity in all models, comparable to the standard reference drug ascorbic acid. The ethanolic extract of Alocasia indica and its gels produced dose-dependent antinociceptive and anti-inflammatory activity, respectively. This finding suggests that ethanolic extract of A. indica possess potent antinociceptive and anti-inflammatory activity possibly due to its free radical scavenging properties.
机译：从各种海芋属物种的叶子中获得的提取物已在印度用作民间疗法，用于治疗各种炎症，包括风湿病和瘀伤。海芋叶片的乙醇提取物。通过使用不同的体外抗氧化剂筛选模型，如清除1，1-二苯基-2-吡啶基肼基（DPPH）自由基，一氧化氮自由基，超氧阴离子自由基和羟基自由基来评估维生素E。通过乙酸诱导的扭体反应，热板法和甩尾法在白化病大鼠中测试抗伤害感受活性。通过使用角叉菜胶诱导的爪水肿测定，福尔马林诱导的爪水肿测定，花生四烯酸诱导的耳水肿测定和二甲苯诱导的耳水肿测定来确定乙醇提取物凝胶的抗炎潜力。该提取物在所有模型中均显示出显着的抗氧化活性，与标准参考药物抗坏血酸相当。海芋的乙醇提取物及其凝胶分别产生剂量依赖性的抗伤害性和抗炎活性。这一发现表明印度A草的乙醇提取物可能具有清除自由基的作用，因此具有强大的镇痛和抗炎活性。

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