...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Young Pharmacists >Incidence of Drug-Drug Interactions among Patients Admitted to the Department of General Medicine in a Tertiary Care Hospital
【24h】

Incidence of Drug-Drug Interactions among Patients Admitted to the Department of General Medicine in a Tertiary Care Hospital

机译：三级医院普通科住院患者中药物相互作用的发生率

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Drug-Drug Interactions (DDIs) contribute to increased rate of morbidity and mortality increasing the need for intense monitoring of patient safety which can be achieved by detecting and preventing morbidities associated with DDIs. Objective and Methodology: The present work was a prospective study carried out for a period of six months, to assess the incidence of DDIs in patients admitted to the Department of General Medicine at a tertiary care hospital. Results: Prescriptions of 411 patients were analysed, out of which 165 (40.15%) prescriptions were identified with potential DDIs whereas clinical manifestations of actual DDIs were observed and reported in 23 (5.6%). A total of 657 DDIs were observed of which 6 (0.9%), 240 (36.5%), 374 (56.9%) and 33 (5.6%) were of contraindicated, major, moderate and minor severity respectively. Based on the mechanism 310 (47.2%) of the identified DDIs were pharmacodynamic and 243 (36.9%) were pharmacokinetic interactions. There was a positive correlation between the number of DDIs and risk factors such as length of hospital stay, number of drugs prescribed and co-morbidities. Conclusion: This study concludes that awareness on the most prevalent DDIs can help the practitioners to prescribe drugs with a low risk for DDIs and prevent the concomitant use of dangerous drug combinations.
机译：背景：药物相互作用（DDI）有助于增加发病率和死亡率，增加了对患者安全性进行严格监控的需求，这可以通过检测和预防与DDI相关的发病率来实现。目的与方法：本研究是一项为期六个月的前瞻性研究，目的是评估三级护理医院普通医学科住院患者的DDI发生率。结果：分析了411例患者的处方，其中165例（40.15％）处方被确定为具有潜在DDI，而观察到并报告了实际DDI的临床表现为23例（5.6％）。总共观察到657个DDI，其中6个（0.9％），240个（36.5％），374个（56.9％）和33个（5.6％）分别为严重，严重，中度和次要严重度。根据该机理，已鉴定的DDI中有310（47.2％）是药代动力学，而243（36.9％）是药代动力学相互作用。 DDI的数量与危险因素（如住院时间，处方药数量和合并症）呈正相关。结论：本研究的结论是，对最普遍的DDI的了解可以帮助从业者开具DDI风险较低的药物，并防止危险药物组合的同时使用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号