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首页> 外文期刊>Journal of Young Pharmacists >Gender-based Early Immunological Response to Antiretroviral Therapy in HIV Patients at a Tertiary Care Hospital in Coastal Karnataka
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Gender-based Early Immunological Response to Antiretroviral Therapy in HIV Patients at a Tertiary Care Hospital in Coastal Karnataka

机译:沿海卡纳塔克邦三级医院的艾滋病毒患者对抗逆转录病毒疗法的基于性别的早期免疫反应

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Background and Objective: To compare the immunological response to antiretroviral therapy between genders and to identify other factors that could affect the immunological response. Methods: This was a prospective, observational study of 171 HIV patients with a follow-up at six months. The exposure to be measured was gender and the outcome of interest included CD4 count (immunological response) which was classified as adequate, suboptimal and immunological failure. Results: A total of 171 patients completed the study out of which 88 (51.5%) were males and 83 (48.5%) were females. Overall, 130 patients out of 171 (76.0%) showed an adequate response at the end of the first six months of ART. The response was comparable in both men and women, and no significant difference was seen (p = 0.216). Though not statistically significant, more than 80% of the patients with a baseline CD4 cell count less than 300 cells/ mm3 showed an adequate response. Also, the baseline BMI (classified as underweight, normal, overweight, obese) did not affect the immunological response significantly. Conclusion: Gender did not play a role in the immunological response following the initiation of antiretroviral therapy in treatment na?ve patients. The baseline CD4 count and the baseline BMI did not significantly affect the immunological response.
机译:背景与目的:比较不同性别对抗逆转录病毒疗法的免疫反应,并确定其他可能影响免疫反应的因素。方法:这是一项针对171名HIV患者的前瞻性观察性研究,在六个月后进行了随访。所测量的暴露程度是性别,感兴趣的结果包括CD4计数(免疫应答),其分类为充分,次优和免疫衰竭。结果:总共171位患者完成了研究,其中88位(51.5%)是男性,83位(48.5%)是女性。总体而言,在ART的前六个月末,171名患者中有130名患者(76.0%)表现出足够的反应。男性和女性的反应相当,并且没有显着差异(p = 0.216)。尽管无统计学意义,但基线CD4细胞计数低于300细胞/ mm 3 的患者中,有80%以上的患者表现出足够的反应。同样,基线BMI(分类为体重过轻,正常,超重,肥胖)对免疫反应没有明显影响。结论:初次接受抗逆转录病毒治疗后,性别在免疫应答中没有作用。基线CD4计数和基线BMI不会显着影响免疫反应。

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