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首页> 外文期刊>Journal of Young Pharmacists >Assess the Clinical Efficacy of Streptokinase in Thrombolysed Patients of Acute ST Segment Elevation Myocardial Infarction
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Assess the Clinical Efficacy of Streptokinase in Thrombolysed Patients of Acute ST Segment Elevation Myocardial Infarction

机译：评估链激酶在急性ST段抬高型心肌梗死的血栓溶解患者中的临床疗效

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Introduction: Acute myocardial infarction is the most important and feared consequence of coronary artery disease. STEMI is the one of that kind and it occurs by formation of a vulnerable plaque from atherosclerosis and transforms into coronary artery thrombosis in the end. Streptokinase has been used as a thrombolytic agent in patients with acute STEMI. It combines with the circulatory plasminogen to form an activator complex and it converts into plasmin, where, the plasmin breaks the fibrin complex in the blood clot. Streptokinase can be given as 1,500,000U a slow I.V infusion over 30 min. Each STEMI subject is different with the aetiology, pain, ST segment elevation. By considering these factors the clinical efficacy of streptokinase will be evaluated. Materials and Methods: A total number of 75 subjects presenting with acute STEMI to the department of cardiology, King George Hospital, Visakhapatnam, and, those were thrombolysed with streptokinase are included in the study. pain was assessed before and 90 min after administration of streptokinase on numerical pain rating scale from 0-10. ST segment resolution was assessed as percentage reduction in ST segment elevation before administration of streptokinase and the reduction of ST segment elevation 90 min after administration of streptokinase. Student t -test and chi-square test were applied to evaluate the results by using software SPSS. Results: A significant resolution in the pain and ST segment elevation were identified by comparing the numerical pain rating scale and ST segment elevation on pre and post streptokinase administration. Conclusion: Streptokinase has been shown to have significant effect on pain resolution and ST segment resolution in subjects with acute ST segment elevation myocardial infarction.
机译：简介：急性心肌梗塞是冠状动脉疾病最重要，最令人恐惧的后果。 STEMI是这种类型的一种，它通过动脉粥样硬化形成易损斑块而发生，最后转变为冠状动脉血栓形成。链激酶已被用作急性STEMI患者的溶栓剂。它与循环型纤溶酶原结合形成活化剂复合物，然后转化为纤溶酶，纤溶酶会破坏血凝块中的纤维蛋白复合物。链激酶可在30分钟内以1,500,000U的速度缓慢静脉输注。每个STEMI受试者的病因，疼痛，ST段抬高均不同。通过考虑这些因素，将评估链激酶的临床疗效。材料和方法：研究对象包括75例在维萨卡帕特南国王乔治医院心脏病科表现为急性STEMI的受试者，并用链激酶对其进行溶栓。在0至10的数字疼痛等级量表上，在施用链激酶之前和之后90分钟评估疼痛。 ST段分辨率的评估是在施用链激酶之前ST段升高降低的百分比和在施用链激酶之后90分钟ST段升高降低的百分比。学生t检验和卡方检验通过使用SPSS软件进行评估。结果：通过比较在施用链激酶之前和之后的数字疼痛等级量表和ST段抬高，可以确定疼痛和ST段抬高的显着缓解。结论：链激酶已被证明对急性ST段抬高型心肌梗死患者的疼痛缓解和ST段分辨能力有显着影响。

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