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首页> 外文期刊>Journal of Young Pharmacists >Formulation of Transfersomal Green Tea (Camellia sinensis L. Kuntze) Leaves Extract Cream and In Vitro Penetration Study Using Franz Difussion Cell
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Formulation of Transfersomal Green Tea (Camellia sinensis L. Kuntze) Leaves Extract Cream and In Vitro Penetration Study Using Franz Difussion Cell

机译：转运体绿茶（茶树）叶子提取物乳膏的配方和Franz扩散细胞的体外渗透研究

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Introduction: Green tea is a natural ingredient that contains polyphenolic compounds in the form of catechin derivatives known as epigallocatechin gallate (EGCG). It has an antioxidant activity that is beneficial for body health. However, EGCG has a considerable molecular weight and high hydrophilicity resulting in the difficulty of skin penetration. The aim of this study was to improve EGCG penetration through the skin by using the formation of lipid nanovesicles, called transfersomes, that was formulated into a cream dosage form. Methods: Transfersomes were prepared by thin layer hydration method in three formulations with different concentration of phospholipid and surfactant. The amount of green tea leaves extract used for all formulations was same, (equal to 3% EGCG). All transfersomes formulation was characterized their physical properties, and the most promising formulation was chosen to be formulated into a cream dosage form. A cream contained untreated extract was prepared as a control. The in vitro penetration study of EGCG from both creams was evaluated using Franz diffusion cells with the abdomen skin of Sprague- Dawley rats as a membrane between the compartments. Results and Discussion: The results showed that F1 was the most promising and optimal formulation with a spherical shape, particle size of 80.6 nm, a polydispersity index of 0.214, a zeta potential at -48.2 ± 1.78 mV, and the highest entrapment efficiency of 49.36 ± 4.03%. The cumulative amount of EGCG penetrated from transfersomal and non transfersomal cream were 1003.61 ± 157.93 μg/cm2 and 400.09 ± 47.53 μg/cm2, respectively (P Conclusion: To summarize, this study demonstrated that formulation of green tea leaves extract into a transfersomal cream dosage form could increase the amount of EGCG penetrated through the skin.
机译：简介：绿茶是一种天然成分，其中含有儿茶素衍生物形式的多酚化合物，称为表没食子儿茶素没食子酸酯（EGCG）。它具有抗氧化活性，对身体健康有益。然而，EGCG具有相当大的分子量和高亲水性，导致皮肤渗透困难。这项研究的目的是通过使用脂质纳米囊泡（称为传递体）的形成来提高EGCG通过皮肤的渗透，该脂质囊泡被配制成乳膏剂型。方法：采用薄层水化法制备三种浓度不同的磷脂和表面活性剂的传递体。用于所有配方的绿茶叶提取物的量是相同的（等于3％EGCG）。所有传递体制剂均已表征其物理性质，并且选择了最有前途的制剂制成乳剂形式。制备含有未处理的提取物的乳膏作为对照。使用Franz扩散池以Sprague-Dawley大鼠的腹部皮肤作为隔室之间的膜，评估了两种乳膏中EGCG的体外渗透研究。结果与讨论：结果表明，F1是最有前途和最佳的配方，球形，粒径为80.6 nm，多分散指数为0.214，zeta电位为-48.2±1.78 mV，最高包封效率为49.36。 ±4.03％。从传递体乳膏和非传递体乳膏中渗透的EGCG的累积量分别为1003.61±157.93μg/ cm2和400.09±47.53μg/ cm2（P结论：综上所述，该研究表明，绿茶提取物的配方已制成传递体乳膏剂形式可以增加通过皮肤渗透的EGCG的量。

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