• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Young Pharmacists >In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers
【24h】

In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

机译：酮洛芬贴剂与乙基纤维素和聚乙烯吡咯烷酮为基质聚合物的体外渗透研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Transdermal patch can release drug to provide systemic pharmacological effect. Matrix used in the patch formula influences the release of the drug. The aim of the study was to evaluate permeation of Ketoprofen patch containing combination of Ethyl Cellulose (EC) and Polyvynil Pyrrolidone (PVP) as matrix. EC is a hydrophobic polymer while PVP is a hydrophilic one. Transdermal formulation containing two polymers with different polarity will provide better permeation results than use only one type of polymer. Ketoprofen 1% was used as a model of active substance in the study. Methods: Ratio of EC and PVP concentration (1:1, 1:3 and 3:1) in patch formula was determined using Simplex Lattice Design (SLD) method. In vitro permeation study was done for 12 h using Franz diffusion cell and shed snake of Phyton reticulatus as a membrane. Amount of the drug released was analyzed using Spectrophotometer UV-Vis (λ = 262 nm). The drug release mechanism was known by determination the drug release kinetics order. Results: The study result showed that the higher PVP concentration was used in the formula, the higher percentage of Ketoprofen permeation was obtained. Patch formula containing EC:PVP in ratio 1:3 had the highest percentage of permeation (93.66%). The drug release kinetics of Ketoprofen from the patch followed zero order kinetics. Conclusion: Combination of EC and PVP in ratio 1:3 resulted the highest percentage of ketoprofen permeation for 12 h (93.66%). The drug release mechanism followed zero order kinetics.
机译：目的：透皮贴剂可以释放药物以提供全身药理作用。贴剂配方中使用的基质会影响药物的释放。该研究的目的是评估酮洛芬贴剂的渗透性，该贴剂包含乙基纤维素（EC）和聚维尼吡咯烷酮（PVP）的组合。 EC是疏水聚合物，而PVP是亲水聚合物。与仅使用一种类型的聚合物相比，含有两种极性不同的聚合物的透皮制剂将提供更好的渗透效果。酮洛芬1％被用作研究中的活性物质模型。方法：采用单晶格设计（SLD）方法测定贴剂配方中EC和PVP浓度的比例（1：1、1：3和3：1）。使用Franz扩散池和网状Phyton的脱落蛇作为膜进行了12 h的体外渗透研究。使用分光光度计UV-Vis（λ= 262 nm）分析释放的药物量。通过确定药物释放动力学顺序可以知道药物释放机理。结果：研究结果表明，配方中使用的PVP浓度越高，酮洛芬的渗透率越高。比例为1：3的EC：PVP的贴剂配方的渗透率最高（93.66％）。酮洛芬从贴剂的释放动力学遵循零级动力学。结论：EC和PVP的比例为1：3组合时，酮洛芬的渗透百分比最高，为12 h（93.66％）。药物释放机理遵循零级动力学。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号