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首页> 外文期刊>Journal of Young Pharmacists >Investigating True β-lactam Allergy in the Outpatient Allergy Clinics at a Public Children’s Hospital, Ceará, Brazil
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Investigating True β-lactam Allergy in the Outpatient Allergy Clinics at a Public Children’s Hospital, Ceará, Brazil

机译：在巴西塞拉州一家公立儿童医院的门诊过敏诊所调查真正的β-内酰胺过敏

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Objective: The aim of the study was to investigate true β-lactam allergy at a public pediatric hospital. Material and Methods: Children and adolescents with allergy symptoms were referred to the Allergy and Immunology Service, Hospital Infantil Albert Sabin, Fortaleza, Brazil. During the allergist interviews, β-lactam drug allergy was suspected in 24 patients. Results: Urticaria, angioedema, erythematous macules and papules were the clinical manifestations most frequently reported in 23 patients with immediate reaction. The drugs implicated were amoxicillin (58.3%), penicillin (20.8%), ceftriaxone (12.5%) and ampicillin (8.4%). The majority of the patients showed negative results for ampicillin, penicillin and ceftriaxone in skin testing and also negative results in oral provocation testing (OPT) to amoxicillin. One patient with clinical history of ceftriaxone allergy showed positive prick test to the drug and negative OPT to amoxicillin. Conclusion: b-lactam drugs are a very useful choice for treatment of bacterial infections in children. In this way, it is reasonable that hypothesis of allergy to those drugs be investigated. For this reason, during consultation, it is necessary that the allergist questions about drug allergy, apart from the original complaint (if it is not directly related to drug allergy). Upon suggestive history, the hypothesis of drug allergy should be ruled out by doing a careful laboratorial and clinical investigation. In order to rationalize the operating and economical costs related to skin testing and OPT, we suggest grouping a number of patients for whom the tests will be performed during a half-day period two to three times a year.
机译：目的：该研究的目的是调查一家公立儿科医院的真正β-内酰胺过敏。材料和方法：有过敏症状的儿童和青少年被转诊至巴西福塔雷萨的Infantil Albert Sabin医院过敏和免疫学服务处。在过敏者访谈中，怀疑有24名患者患有β-内酰胺类药物过敏。结果：荨麻疹，血管性水肿，红斑，丘疹是23例立即反应的患者中最常报告的临床表现。涉及的药物是阿莫西林（58.3％），青霉素（20.8％），头孢曲松（12.5％）和氨苄青霉素（8.4％）。大多数患者在皮肤测试中对氨苄西林，青霉素和头孢曲松显示阴性结果，对阿莫西林的口服激发试验（OPT）也显示阴性结果。一名具有头孢曲松过敏临床病史的患者对药物的点刺试验显示阳性，对阿莫西林的OPT显示阴性。结论：β-内酰胺类药物是治疗儿童细菌感染的非常有用的选择。通过这种方式，对这些药物过敏的假设进行调查是合理的。因此，在咨询过程中，除了最初的投诉（如果与药物过敏不直接相关）之外，过敏者还必须对药物过敏提出疑问。根据提示性病史，应通过仔细的实验​​室和临床研究排除药物过敏的假说。为了合理化与皮肤测试和OPT相关的运营和经济成本，我们建议将将在半天时间内进行测试的一些患者分组，每年进行两次至三次。

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