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首页> 外文期刊>Journal of Young Pharmacists >Peritoneal mast cell stabilization and free radical scavenging activity of Yucca gloriosa L
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Peritoneal mast cell stabilization and free radical scavenging activity of Yucca gloriosa L

机译：丝兰的腹膜肥大细胞稳定和自由基清除活性

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Objective: To investigate in vitro antioxidant and mast cell stabilization potential Yucca gloriosa L. Methods: The aerial parts of Yucca gloriosa L. (Family- Agavaceae ) were successively extracted with ethanol, 50% aqueous-ethanolic and aqueous to prepare an extract of the plant. Preliminary phytochemical tests, total phenol and flavonoid estimation were analyzed in Y. gloriosa L. extract. Furthermore, in vitro antioxidant activity was evaluated such as DPPH method, ABTS assay, superoxide assay, nitric oxide assay and lipid peroxidation inhibition assay. The extract of YGE, 50% YGE and YGA (1, 10 and 100μg/ml) was studied for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80. Result: The result revealed that YGE showed highest concentration of phenol and flavonoid compounds. Free radical scavenger activity and mast cell activity had been identified in YGE, 50%YGE and YGA extracts. The Free radical scavenger study revealed that the YGE, 50%YGE & YGA extracts of Y. gloriosa L. showed significant activity in DPPH method, Nitric oxide assay, ABTS cation decolorization assay, superoxide assay and lipid peroxidase assay. All the extracts showed ability to prevent oxidation when compare with standard markers. Upon further investigation for mast cell activity, of YGE extracts showed significant increase the number of intact cells when compared with C48/80 at the concentrations of 10 and 100 μg/mg when compare to other extracts. Conclusion: This finding provides suggested that Y. gloriosa L. is a potential candidate in herbal medicine for allergic asthma. Due to its ability to inhibit mast cell derived immediate-type I allergic reactions. It virtues further work towards the isolation of phytoconstituents from Y. gloriosa L.
机译：目的：探讨丝兰（Yucca gloriosa L.）的体外抗氧化剂和肥大细胞稳定的潜力。方法：先后用乙醇，50％的乙醇水溶液和水相提取丝兰的地上部分（家庭-龙舌兰科）制备其提取物。厂。初步的植物化学测试，总酚和类黄酮的估计分析在光耶尔酵母中提取。此外，评价了体外抗氧化剂活性，例如DPPH法，ABTS测定，超氧化物测定，一氧化氮测定和脂质过氧化抑制测定。研究了YGE，50％YGE和YGA（1、10和100μg/ ml）的提取物在C 48/80诱导的大鼠肠系膜制剂中对腹膜肥大细胞的稳定作用。结果：结果表明，YGE显示出最高浓度的苯酚和类黄酮化合物。在YGE，50％YGE和YGA提取物中已鉴定出自由基清除剂活性和肥大细胞活性。自由基清除剂研究显示，Y。gloriosa L.的YGE，50％YGE和YGA提取物在DPPH方法，一氧化氮测定，ABTS阳离子脱色测定，超氧化物测定和脂质过氧化物酶测定中显示出显着活性。与标准标记物相比，所有提取物均具有防止氧化的能力。在进一步研究肥大细胞活性后，与C48 / 80相比，YGE提取物在浓度为10和100μg/ mg时与其他提取物相比，完整细胞数量显着增加。结论：这一发现表明，Y。gloriosa L.是过敏性哮喘中草药的潜在候选者。由于其具有抑制肥大细胞衍生的即时I型过敏反应的能力。它有利于进一步从油酸耶尔森氏菌中分离植物成分。

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