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首页> 外文期刊>Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland >Distribution of carbapenem resistance determinants among epidemic and non-epidemic types of Acinetobacter species in Japan
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Distribution of carbapenem resistance determinants among epidemic and non-epidemic types of Acinetobacter species in Japan

机译：碳青霉烯耐药性决定因素在日本流行和非流行类型的不动杆菌中的分布

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摘要

We performed a comparative molecular analysis on three types of clinically isolated Acinetobacter spp.: epidemic sequence types (STs) of Acinetobacter baumannii (epidemic ST-AB), non-epidemic sequence types of A. baumannii (non-epidemic ST-AB) and non-baumannii Acinetobacter spp. A total of 87 isolates – 46 A. baumannii, 25 A. pittii and 16 A. nosocomialis – from 43 hospitals were analysed. Of these, 31 A. baumannii isolates were ST1 or ST2 according to the Pasteur Institute multilocus sequence typing scheme and were defined as epidemic ST-AB. The other 15 A. baumannii isolates were defined as non-epidemic ST-AB. The epidemic ST-AB isolates harboured the bla OXA-23-like gene or had an ISAba1 element upstream of bla OXA-51-like, or both, whereas non-epidemic ST-AB and non-baumannii Acinetobacter spp. isolates harboured bla OXA-58-like or metallo-β-lactamase genes, or both. The proportion of multidrug-resistant isolates was significantly higher in the epidemic ST-AB isolates (48 %) than that in the other types of Acinetobacter isolates (5 %) (P&0.05). In addition, epidemic ST-AB isolates exhibited a relatively higher proportion of fluoroquinolone resistance. We demonstrated that, in terms of genotypes and phenotypes of antimicrobial resistance, non-epidemic ST-AB isolates shared more similarity with non-baumannii Acinetobacter spp. isolates than with epidemic ST-AB isolates, regardless of bacterial species. In addition, this study revealed that, even in Japan, where IMP-type metallo-β-lactamase producers are endemic, epidemic ST-AB harbouring bla IMP have not yet emerged.
机译：我们对三种临床分离的不动杆菌属进行了比较分子分析：鲍曼不动杆菌的流行序列类型（ST）（流行ST-AB），鲍曼不动杆菌的非流行序列类型（非流行ST-AB）和非鲍曼不动杆菌属共分析了来自43家医院的87株分离菌，其中包括46株鲍曼不动杆菌，25株匹氏杆菌和16株医院内芽孢杆菌。其中，根据巴斯德研究所的多基因座序列分型方案，有31种鲍曼不动杆菌为ST1或ST2，被定义为流行ST-AB。其他15种鲍曼不动杆菌的分离株定义为非流行性ST-AB。流行的ST-AB分离株具有bla OXA-23样基因，或在bla OXA-51样或两者兼有的上游具有ISAba1元件，而非流行ST-AB和非鲍曼不动杆菌属。分离株带有bla OXA-58样或金属-β-内酰胺酶基因，或两者都有。流行的ST-AB分离株中多药耐药分离株的比例（48％）明显高于其他类型的不动杆菌分离株（5％）（P <0.05）。另外，流行的ST-AB分离株表现出相对较高的氟喹诺酮耐药性比例。我们证明，就抗药性的基因型和表型而言，非流行性ST-AB分离株与非鲍曼不动杆菌属具有更多相似性。分离株比流行ST-AB分离株要大，而与细菌种类无关。另外，这项研究表明，即使在日本，IMP型金属β-内酰胺酶的生产国是地方性的，带有bla IMP的流行ST-AB尚未出现。

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