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首页> 外文期刊>BioMed research international >Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins
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Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins

机译：花青素化学预防作用背后的分子机制

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Anthocyanins are polyphenolic ring-based flavonoids, and are widespread in fruits and vegetables of red-blue color. Epidemiological investigations and animal experiments have indicated that anthocyanins may contribute to cancer chemoprevention. The studies on the mechanism have been done recently at molecular level. This review summarizes current molecular bases for anthocyanidins on several key steps involved in cancer chemoprevention: (i) inhibition of anthocyanidins in cell transformation through targeting mitogen-activated protein kinase (MAPK) pathway and activator protein 1 (AP-1) factor; (ii) suppression of anthocyanidins in inflammation and carcinogenesis through targeting nuclear factorkappaB (NF-κB) pathway andcyclooxygenase2 (COX-2) gene; (iii) apoptotic induction of cancer cells by anthocyanidins through reactive oxygen species (ROS) / c-Jun NH2-terminal kinase (JNK)-mediated caspase activation. These data provide a first molecular view of anthocyanidins contributing to cancer chemoprevention.
机译：花青素是基于多酚环的类黄酮，广泛存在于红色和蓝色的水果和蔬菜中。流行病学调查和动物实验表明，花色苷可能有助于化学预防癌症。最近在分子水平上已经对该机理进行了研究。这篇综述总结了花色苷分子在癌症化学预防中涉及的几个关键步骤的当前分子基础：（i）通过靶向有丝分裂原激活的蛋白激酶（MAPK）途径和激活蛋白1（AP-1）因子抑制花色素苷在细胞转化中的作用; （ii）通过靶向核因子κB（NF-κB）途径和环氧合酶2（COX-2）基因来抑制花色苷在炎症和致癌中的作用; （iii）花青素通过活性氧（ROS）/ c-Jun NH2-末端激酶（JNK）介导的半胱天冬酶激活来凋亡诱导癌细胞。这些数据提供了花青素有助于癌症化学预防的第一个分子观点。

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