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首页> 外文期刊>BMC Genomics >IMGD: an integrated platform supporting comparative genomics and phylogenetics of insect mitochondrial genomes
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IMGD: an integrated platform supporting comparative genomics and phylogenetics of insect mitochondrial genomes

机译：IMGD：一个集成平台，支持昆虫线粒体基因组的比较基因组学和系统发育

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Background Sequences and organization of the mitochondrial genome have been used as markers to investigate evolutionary history and relationships in many taxonomic groups. The rapidly increasing mitochondrial genome sequences from diverse insects provide ample opportunities to explore various global evolutionary questions in the superclass Hexapoda. To adequately support such questions, it is imperative to establish an informatics platform that facilitates the retrieval and utilization of available mitochondrial genome sequence data. Results The Insect Mitochondrial Genome Database (IMGD) is a new integrated platform that archives the mitochondrial genome sequences from 25,747 hexapod species, including 112 completely sequenced and 20 nearly completed genomes and 113,985 partially sequenced mitochondrial genomes. The Species-driven User Interface (SUI) of IMGD supports data retrieval and diverse analyses at multi-taxon levels. The Phyloviewer implemented in IMGD provides three methods for drawing phylogenetic trees and displays the resulting trees on the web. The SNP database incorporated to IMGD presents the distribution of SNPs and INDELs in the mitochondrial genomes of multiple isolates within eight species. A newly developed comparative SNU Genome Browser supports the graphical presentation and interactive interface for the identified SNPs/INDELs. Conclusion The IMGD provides a solid foundation for the comparative mitochondrial genomics and phylogenetics of insects. All data and functions described here are available at the web site http://www.imgd.org/ webcite .
机译：背景线粒体基因组的序列和组织已被用作研究许多生物分类组进化史和关系的标记。来自各种昆虫的线粒体基因组序列迅速增加，为探索超六足纲中的各种全球进化问题提供了充足的机会。为了充分支持这些问题，必须建立一个信息学平台，以促进对可用线粒体基因组序列数据的检索和利用。结果昆虫线粒体基因组数据库（IMGD）是一个新的集成平台，可存档来自25,747种六足动物的线粒体基因组序列，其中包括112个完全测序的基因组和20个接近完成的基因组，以及113,985个部分测序的线粒体基因组。 IMGD的物种驱动用户界面（SUI）支持多分类群级别的数据检索和各种分析。 IMGD中实现的Phyloviewer提供了三种绘制系统发育树的方法，并将所得树显示在网络上。整合到IMGD中的SNP数据库显示了SNP和INDEL在八种物种内多种分离物的线粒体基因组中的分布。新开发的比较型SNU Genome Browser支持已标识的SNP / INDEL的图形表示和交互式界面。结论IMGD为比较昆虫的线粒体基因组学和系统发育提供了坚实的基础。此处描述的所有数据和功能都可以从网站http://www.imgd.org/webcite获得。

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