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首页> 外文期刊>BMC Genomics >ChlamyCyc: an integrative systems biology database and web-portal for Chlamydomonas reinhardtii
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ChlamyCyc: an integrative systems biology database and web-portal for Chlamydomonas reinhardtii

机译：ChlamyCyc：莱茵衣藻的集成系统生物学数据库和网络门户

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Background The unicellular green alga Chlamydomonas reinhardtii is an important eukaryotic model organism for the study of photosynthesis and plant growth. In the era of modern high-throughput technologies there is an imperative need to integrate large-scale data sets from high-throughput experimental techniques using computational methods and database resources to provide comprehensive information about the molecular and cellular organization of a single organism. Results In the framework of the German Systems Biology initiative GoFORSYS, a pathway database and web-portal for Chlamydomonas (ChlamyCyc) was established, which currently features about 250 metabolic pathways with associated genes, enzymes, and compound information. ChlamyCyc was assembled using an integrative approach combining the recently published genome sequence, bioinformatics methods, and experimental data from metabolomics and proteomics experiments. We analyzed and integrated a combination of primary and secondary database resources, such as existing genome annotations from JGI, EST collections, orthology information, and MapMan classification. Conclusion ChlamyCyc provides a curated and integrated systems biology repository that will enable and assist in systematic studies of fundamental cellular processes in Chlamydomonas. The ChlamyCyc database and web-portal is freely available under http://chlamycyc.mpimp-golm.mpg.de webcite .
机译：背景技术单细胞绿藻莱茵衣藻是用于光合作用和植物生长研究的重要的真核生物模型生物。在现代高通量技术时代，迫切需要使用计算方法和数据库资源集成来自高通量实验技术的大规模数据集，以提供有关单个生物的分子和细胞组织的全面信息。结果在德国系统生物学计划GoFORSYS的框架内，建立了衣原体（ChlamyCyc）的途径数据库和网络门户，目前具有约250种代谢途径以及相关的基因，酶和化合物信息。 ChlamyCyc使用整合方法进行组装，该方法结合了最近发布的基因组序列，生物信息学方法以及来自代谢组学和蛋白质组学实验的实验数据。我们分析和集成了主要和辅助数据库资源的组合，例如来自JGI，EST集合，正畸信息和MapMan分类的现有基因组注释。结论ChlamyCyc提供了一个经过精心设计和集成的系统生物学资料库，它将能够并协助系统地研究衣藻的基本细胞过程。可在http://chlamycyc.mpimp-golm.mpg.de webcite下免费获得ChlamyCyc数据库和Web门户。

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