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首页> 外文期刊>BMJ Open >Real-time continuous glucose monitoring versus conventional glucose monitoring in critically ill patients: a systematic review study protocol
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Real-time continuous glucose monitoring versus conventional glucose monitoring in critically ill patients: a systematic review study protocol

机译：危重患者实时连续血糖监测与常规血糖监测的系统回顾研究方案

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Introduction Stress-induced hyperglycaemia, which has been shown to be associated with an unfavourable prognosis, is common among critically ill patients. Additionally, it has been reported that hypoglycaemia and high glucose variabilities are also associated with adverse outcomes. Thus, continuous glucose monitoring (CGM) may be the optimal method to detect severe hypoglycaemia, hyperglycaemia and decrease glucose excursion. However, the overall accuracy and reliability of CGM systems and the effects of CGM systems on glucose control and prognosis in critically ill patients remain inconclusive. Therefore, we will conduct a systematic review and meta-analysis to clarify the associations between CGM systems and clinical outcome. Methods and analysis We will search PubMed, EMBASE and the Cochrane Library from inception to October 2014. Studies comparing CGM systems with any other glucose monitoring methods in critically ill patients will be eligible for our meta-analysis. The primary endpoints include the incidence of hypoglycaemia and hyperglycaemia, mean glucose level, and percentage of time within the target range. The second endpoints include intensive care unit (ICU) mortality, hospital mortality, duration of mechanical ventilation, length of ICU and hospital stay, and the Pearson correlation coefficient and the results of error grid analysis. In addition, we will record all complications (eg, acquired infections) in control and intervention groups and local adverse events in intervention groups (eg, bleeding or infections). Ethics and dissemination Ethics approval is not required as this is a protocol for a systematic review. The findings will be disseminated in a peer-reviewed journal and presented at a relevant conference. Trial registration number PROSPERO registration number: CRD42014013488.
机译：简介应激诱发的高血糖症已被证明与不良预后相关，在重症患者中很常见。另外，已经报道低血糖和高葡萄糖变异性也与不良结果相关。因此，连续血糖监测（CGM）可能是检测严重低血糖，高血糖并减少葡萄糖偏移的最佳方法。然而，CGM系统的总体准确性和可靠性以及CGM系统对危重患者血糖控制和预后的影响尚无定论。因此，我们将进行系统的综述和荟萃分析，以阐明CGM系统与临床结果之间的关联。方法和分析从开始到2014年10月，我们将搜索PubMed，EMBASE和Cochrane库。将重症患者的CGM系统与任何其他葡萄糖监测方法进行比较的研究将符合我们的荟萃分析的条件。主要终点包括低血糖和高血糖的发生率，平均血糖水平以及在目标范围内的时间百分比。第二个终点包括重症监护病房（ICU）死亡率，医院死亡率，机械通气时间，ICU长度和住院时间，以及Pearson相关系数和误差网格分析结果。此外，我们将记录对照组和干预组的所有并发症（例如获得性感染）以及干预组的局部不良事件（例如出血或感染）。道德与传播不需要道德批准，因为这是系统审查的协议。调查结果将在经过同行评审的期刊中分发，并在相关会议上进行介绍。试用注册号PROSPERO注册号：CRD42014013488。

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