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首页> 外文期刊>Diabetes research and clinical practice >The effect of continuous subcutaneous glucose monitoring (CGMS) versus intermittent whole blood finger-stick glucose monitoring (SBGM) on hemoglobin A1c (HBA1c) levels in Type I diabetic patients: a systematic review.
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The effect of continuous subcutaneous glucose monitoring (CGMS) versus intermittent whole blood finger-stick glucose monitoring (SBGM) on hemoglobin A1c (HBA1c) levels in Type I diabetic patients: a systematic review.

机译：连续皮下葡萄糖监测（CGMS）与间歇性全血手指葡萄糖监测（SBGM）对I型糖尿病患者血红蛋白A1c（HBA1c）水平的影响：系统评价。

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BACKGROUND AND PURPOSE: Continuous glucose monitoring (CGMS) is a relatively new technology that measures interstitial glucose every 5 min for 72 h. The resulting profile provides a more comprehensive measure of glycemic excursions than intermittent self-blood finger-stick glucose monitoring (SBGM) and thus could potentially improve diabetes control. We performed a meta-analysis of randomized controlled trials comparing CGMS and SBGM in Type 1 diabetic patients. Our aim was to determine whether CGMS leads to better hemoglobin A1c (HBA1c) levels, a marker of long-term vascular risk. METHODS: Randomized controlled trials comparing CGMS and SBGM in Type 1 diabetic patients were identified using both manual and electronic searches of the literature in MEDLINE, EMBASE, PUBMED and Cochrane Central Registry of Controlled Trials from 1996 to March 2007. Relevant studies were independently selected by two reviewers, who also extracted data on study design, quality and effect on HBA1c levels. Data from all trials were pooled using a random effects model. RESULTS: Seven studies with a total of 335 patients fulfilled the inclusion criteria. Five studies were confined to the pediatric population (age18 years). Study duration varied from 12 to 24 weeks. Compared with SBGM, CGMS was associated with a non-significant reduction in HBA1c (0.22%; 95% CI: -0.439% to 0.004%, p=0.055). CONCLUSIONS: There is insufficient evidence to support the notion that CGMS provides a superior benefit over SBGM in terms of HBA1c reduction. There was some indication of improved detection of asymptomatic nocturnal hypoglycemia in the CGMS group.
机译：背景与目的：连续血糖监测（CGMS）是一项相对较新的技术，它每5分钟测量72小时间质葡萄糖。与间歇性自血指尖葡萄糖监测（SBGM）相比，所得到的结果提供了更完整的血糖波动测量指标，因此有可能改善糖尿病控制。我们对1型糖尿病患者的CGMS和SBGM进行了随机对照试验的荟萃分析。我们的目的是确定CGMS是否能导致更好的血红蛋白A1c（HBA1c）水平，这是长期血管危险的标志。方法：使用1996年至2007年3月在MEDLINE，EMBASE，PUBMED和Cochrane对照试验中心注册表中进行手工和电子检索的文献，对比较1型糖尿病患者CGMS和SBGM的随机对照试验进行了确定。两名审稿人，他们还从研究设计，质量和对HBA1c水平的影响中提取数据。使用随机效应模型汇总所有试验的数据。结果：共有335名患者的7项研究符合纳入标准。五项研究仅限于儿科人群（年龄<18岁）。研究持续时间从12周到24周不等。与SBGM相比，CGMS与HBA1c的无显着降低有关（0.22％; 95％CI：-0.439％至0.004％，p = 0.055）。结论：没有足够的证据支持以下观点：CGMS在降低HBA1c方面比SBGM具有优越的优势。有迹象表明，CGMS组无症状夜间低血糖的检测有所改善。

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