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首页> 外文期刊>BMJ Open >Effects of environmental and genetic risk factors for salt sensitivity on blood pressure in northern China: the systemic epidemiology of salt sensitivity (EpiSS) cohort study
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Effects of environmental and genetic risk factors for salt sensitivity on blood pressure in northern China: the systemic epidemiology of salt sensitivity (EpiSS) cohort study

机译：盐敏感性的环境和遗传危险因素对中国北方地区血压的影响：盐敏感性（EpiSS）队列研究的系统流行病学

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Purpose The systemic epidemiology of salt sensitivity (EpiSS) study aims to combine molecular biology, epidemiology and bioinformatics methods to discover the potential causes of salt sensitivity of blood pressure (SSBP) using single-nucleotide polymorphisms in the genome and non-coding RNAs in the transcriptome to uncover both the genetic and environmental factors of SSBP.Participants Between July 2014 and July 2016, we enrolled adults from 11 study centres in Beijing and Liaoning Province; participants were of the Han population and were 35–70 years of age. We collected blood samples, spot urine samples and 24-hour urine samples, in addition to baseline data on demographics, health-related lifestyle factors, chronic diseases, family history of illness and anthropometric information through face-to-face interviews using a standardised questionnaire. EpiSS uses the modified Sullivan’s acute oral saline load and diuresis shrinkage test (MSAOSL-DST) to evaluate the effects of salt on blood pressure.Findings to date In total, 2163 participants were included in the EpiSS, of which 2144 participants completed the questionnaire, 2120 (98.0%) completed the MSAOSL-DST and 2083 (96.3%) provided a 24-hour urine sample. A total of 2057 participants (1501 women and 556 men) completed all the steps of the investigation and were included in the analysis. Among them, 583 (28.3%) subjects were classified as having salt sensitivity of blood pressure, and 1061 (51.6%) had hypertension.Future plans The next step of our study is to evaluate the incidence of cardiovascular disease in the participants. Biennial follow-up, including face-to-face questionnaire surveys, laboratory measurements of blood, urinary creatinine, glomerular filtration rate and anthropometric measurements, will occur two additional times. DNA and RNA will be collected for subsequent genetic biomarker studies. We plan on screening the salt-sensitive-related gene loci and non-coding RNAs based on relative environmental risk factors.Trial registration number ChiCTR-EOC-16009980; Pre-results.
机译：目的盐敏感性（EpiSS）的系统流行病学研究旨在结合分子生物学，流行病学和生物信息学方法，利用基因组中的单核苷酸多态性和非编码RNA来发现血压盐敏感性（SSBP）的潜在原因。转录组揭示了SSBP的遗传和环境因素。参与者2014年7月至2016年7月，我们从北京和辽宁省的11个研究中心招募了成年人;参与者为汉族，年龄在35-70岁之间。除了使用人口统计学，健康相关的生活方式因素，慢性疾病，家族病史和人体测量学信息的基线数据，还通过标准化问卷通过面对面访谈收集了血液样本，现场尿液样本和24小时尿液样本。 EpiSS使用改良的Sullivan急性口服盐水负荷量和利尿收缩试验（MSAOSL-DST）来评估盐对血压的影响。迄今为止，调查结果总计包括2163名参与者，其中2144名参与者填写了问卷， 2120（98.0％）完成了MSAOSL-DST，2083（96.3％）提供了24小时尿液样本。共有2057名参与者（1501名女性和556名男性）完成了调查的所有步骤，并被纳入分析。其中，有583名（28.3％）的受试者被归类为对血压具有盐敏感性，而1061名（51.6％）患有高血压。未来计划我们的下一步是评估受试者的心血管疾病发生率。每两年进行一次随访，包括面对面的问卷调查，实验室血液测量，尿肌酐，肾小球滤过率和人体测量学。 DNA和RNA将被收集用于随后的遗传生物标记研究。我们计划根据相对的环境危险因素，筛选盐敏感相关的基因位点和非编码RNA。试验注册号ChiCTR-EOC-16009980;结果。

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