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首页> 外文期刊>BMJ Open >Diabetes & Women’s Health (DWH) Study: an observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark
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Diabetes & Women’s Health (DWH) Study: an observational study of long-term health consequences of gestational diabetes, their determinants and underlying mechanisms in the USA and Denmark

机译：糖尿病与女性健康（DWH）研究：在美国和丹麦，妊娠糖尿病的长期健康后果，其决定因素和潜在机制的观察性研究

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Purpose Women who experience gestational diabetes mellitus (GDM) are at exceptionally high-risk of developing type 2 diabetes (T2DM) later in life. However, limited information is available about genetic and environmental factors that are implicated in the progression from GDM to T2DM.Participants The Diabetes & Women’s Health (DWH) Study applied a hybrid design, which combined new prospective data collection with existing data in two prospective cohorts, the Danish National Birth Cohort (DNBC) and the Nurses’ Health Study II (NHS II). In total, the DWH Study identified 7759 women with a GDM diagnosis from both cohorts; 4457 women participated in the DWH Study data collection, which included two cycles of follow-up from 2012 to 2014 and 2014 to 2016.Findings to date Progression from GDM to T2DM was high. In the NHS II group, by 2013, 23.1% (n=846/3667) developed T2DM. In the DNBC group, at cycle 1 (2012–2014), the progression rate was even higher: 27.2% (n=215/790) had developed T2DM. Furthermore, we have shown that women who had GDM experienced a significantly greater risk of hypertension and cardiovascular diseases, as well as early stages of glomerular hyperfiltration and renal damage. Moreover, the DWH Study findings have shown that healthful diet and lifestyle factors and weight control were related to a lower risk of T2DM, hypertension and cardiovascular diseases.Future plans Primary data collection for the DWH Study is complete and investigators are currently investigating interactions of the abovementioned modifiable factors with T2DM genetic susceptibility in determining the risk of progression from GDM to T2DM. Findings from ongoing work will provide further insights for identifying more precise prevention strategies for T2DM and comorbidities in this high-risk population. Future work will examine novel biomarkers of health and disease in this cohort.
机译：目的患有妊娠糖尿病（GDM）的女性在生命后期罹患2型糖尿病（T2DM）的风险特别高。然而，关于遗传和环境因素的信息很少，这些因素与从GDM到T2DM的发展有关。参与者糖尿病与女性健康（DWH）研究采用了混合设计，将新的前瞻性数据收集与两个前瞻性队列中的现有数据结合在一起，丹麦国家出生队列（DNBC）和护士健康研究II（NHS II）。 DWH研究总共从这两个队列中鉴定出7759名诊断为GDM的妇女。 4457名妇女参加了DWH研究数据收集，其中包括2012年至2014年和2014年至2016年的两个随访周期。迄今为止的发现从GDM到T2DM的进展很高。在NHS II组中，到2013年，有23.1％（n = 846/3667）开发了T2DM。在DNBC组中，在第1周期（2012-2014），进展速度甚至更高：27.2％（n = 215/790）患上了T2DM。此外，我们发现患有GDM的女性患高血压和心血管疾病的风险显着增加，以及肾小球超滤和肾损害的早期阶段。此外，DWH研究的结果表明，健康的饮食和生活方式因素以及体重控制与降低T2DM，高血压和心血管疾病的风险有关。未来计划DWH研究的主要数据收集已经完成，并且研究者目前正在调查这种疾病的相互作用。上述具有T2DM遗传易感性的可变因素，可确定从GDM演变为T2DM的风险。正在进行的工作得出的结果将为在此高风险人群中确定更精确的T2DM预防和合并症的预防策略提供更多见识。未来的工作将研究该队列中健康和疾病的新型生物标志物。

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