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首页> 外文期刊>British Journal of Cancer >The effect of Corynebacterium parvum therapy on immunoglobulin class and IgG subclass levels in cancer patients
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The effect of Corynebacterium parvum therapy on immunoglobulin class and IgG subclass levels in cancer patients

机译：小棒杆菌治疗对癌症患者免疫球蛋白和IgG亚类水平的影响

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Detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with Corynebacterium parvum (C. parvum). These patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. They all received an initial i.v. infusion of 20 mg of a formol killed suspension of C. parvum followed by 2 mg (i.m.) at weekly intervals for 10-11 weeks. This protocol consistently resulted in an increase in the circulating IgG levels of all patients but had a variable effect on their IgA, IgM and IgE levels. Increases in the concentration of all 4 IgG subclasses contributed to the overall increase in IgG levels and these changes ranked IgG2 greater than IgG1 greater than IgG3 = IgG4. It also had an inconsistent effect upon the levels of alpha-macroglobulin in pregnancy but the levels of normal serum alpha2-macroglobulin were virtually unchanged. Pre-existing antibodies to C. parvum were noted in all the patients. Titres rose appreciably following C. parvum administration and remained at high, though fluctuating levels, throughout the 100-day period of observation. Absorption studies suggested that the development of antibodies to C. parvum accounted in part for the increased IgG levels noted following this form of therapy. The significance of these changes in relation to the possible anti-tumour effect of C. parvum is discussed.
机译：在接受小肠棒状杆菌（C. parvum）非特异性免疫治疗的一小群癌症患者中，进行了详细的血清学研究。这些患者包括4例复发性恶性黑色素瘤，2例胃癌和2例复发乳腺癌。他们都收到了初始i.v.每周10到11周，每次输注20 mg甲壳虫杀死的小孢梭菌悬浮液，然后输注2 mg（i.m.）。该方案始终导致所有患者的循环IgG水平增加，但对其IgA，IgM和IgE水平具有可变的影响。所有4种IgG亚类的浓度增加都导致IgG水平总体增加，这些变化使IgG2大于IgG1大于IgG3 = IgG4。它也对孕妇的α-巨球蛋白水平有不一致的影响，但正常的血清α2-巨球蛋白水平实际上没有变化。在所有患者中都注意到了小球藻的既有抗体。细小隐孢子虫施用后，滴度明显上升，并且在整个100天的观察期内保持较高的水平，尽管有所波动。吸收研究表明，针对小隐孢子虫的抗体的发展部分解释了这种治疗形式后IgG水平的升高。讨论了这些变化与小隐孢子虫可能的抗肿瘤作用有关的意义。

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