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首页> 外文期刊>British Journal of Cancer >A Transferable “Resistance Factor” from in vitro Cultured MDMS-Resistant Yoshida Sarcoma Cells
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A Transferable “Resistance Factor” from in vitro Cultured MDMS-Resistant Yoshida Sarcoma Cells

机译：来自体外培养的耐MDMS的吉田肉瘤细胞的可转移“抵抗因子”

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摘要

Cells of the methylene dimethanesulphonate-(MDMS)-resistant Yoshida sarcoma cell line contain a low molecular weight “resistance factor” which is present in the culture medium of these cells and may be utilized by MDMS-sensitive Yoshida sarcoma cells either by co-culturing the two cell lines or by culturing the MDMS-sensitive Yoshida cells in a medium containing 20% used medium of MDMS-resistant Yoshida cells or in the presence of dialysed medium from resistant cells. The “resistance factor” does not inactivate the drug itself or its metabolites, and it has no influence on the sensitivity of the cells if added after MDMS treatment. Twenty-four hours seems to be enough time for the transfer of the resistance factor, but its effect on whole populations decreases within 24 hours of ceasing the supply. The relationship between these findings and the known phenomena of metabolic co-operation are discussed.
机译：耐亚甲基二甲磺酸酯（MDMS）的吉田肉瘤细胞系的细胞含有低分子量“抵抗因子”，这些分子存在于这些细胞的培养基中，可以被MDMS敏感的吉田肉瘤细胞通过共培养利用两种细胞系，或在含有20％使用过的耐MDMS的吉田细胞培养基中或存在来自抗性细胞的透析培养基中培养MDMS敏感的吉田细胞。 “抗性因子”不会使药物本身或其代谢产物失活，并且如果在MDMS处理后添加，则不会影响细胞的敏感性。 24小时似乎足以转移抵抗因子，但在停止供应后24小时内，它对整个种群的影响就会降低。讨论了这些发现与代谢合作的已知现象之间的关系。

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