...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British Journal of Cancer >Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival
【24h】

Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival

机译：使用图像分析评估乳腺癌中新的增殖标志物MIB1：与其他预后因素和生存的关联

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The 'growth fraction' of tumours can now be assessed on paraffin sections of tissues using the monoclonal antibody MIB1 by a microwave antigen retrieval technique. The MIB1 labelling index was studied using a CAS 200 image analyser in 177 tumours from women with primary operable breast carcinoma in whom long-term follow-up data were known. Statistical analysis showed a strong association between the MIB1 labelling index and histological grade (P < 0.001), tumour size (P = 0.002), tumour type (P < 0.001) and also patient survival (P < 0.001). No association with lymph node stage (P = 0.974) or regional recurrence (P = 0.185), the presence or absence of distant metastases (P = 0.418), patient age (P = 0.309), menopausal status (P = 0.181) or oestrogen receptor status (P = 0.401) was found in this group of patients. In multivariate analysis for survival, when histological grade, lymph node stage and tumour size were included as well as the MIB1 labelling index, each was found to be of independent significance. If histological grade was not included, MIB1 replaced it as the most important variable predicting for survival in this group of patients. The results suggest that the tumour growth fraction, as assessed by the MIB1 labelling index, is an important predictor of survival.
机译：现在可以使用单克隆抗体MIB1通过微波抗原回收技术在组织的石蜡切片上评估肿瘤的“生长分数”。 MIB1标记指数是使用CAS 200图像分析仪在177例原发性可手术乳腺癌妇女的肿瘤中进行的，这些妇女的长期随访资料已知。统计分析表明，MIB1标记指数与组织学分级（P <0.001），肿瘤大小（P = 0.002），肿瘤类型（P <0.001）以及患者生存率（P <0.001）之间有很强的关联。与淋巴结分期（P = 0.974）或区域复发（P = 0.185），是否存在远处转移（P = 0.418），患者年龄（P = 0.309），绝经状态（P = 0.181）或雌激素无关在这组患者中发现受体状态（P = 0.401）。在生存率的多变量分析中，当包括组织学分级，淋巴结分期和肿瘤大小以及MIB1标记指数时，发现每一项都具有独立意义。如果不包括组织学分级，则MIB1将其取代为预测该组患者生存的最重要变量。结果表明，通过MIB1标记指数评估的肿瘤生长分数是生存的重要预测指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号