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首页> 外文期刊>British Journal of Cancer >Stability of oestrogen receptor status in sequential biopsies from patients with breast cancer
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Stability of oestrogen receptor status in sequential biopsies from patients with breast cancer

机译：乳腺癌患者连续活检中雌激素受体状态的稳定性

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Sequential biopsies of breast cancer tissue were obtained from a total of 210 women in order to assess any change in oestrogen receptor (ER) status arising spontaneously or as a result of intervening therapy. A combined assay measuring both cytosol and nuclear oestrogen receptors was used for all samples. One hundred and fifty-five patients had biopsies of their primary tumour and of a later loco-regional recurrence; 26 had biopsies of their primary tumour and a recurrence or new primary in the opposite breast; and 29 had sequential biopsies of recurrent disease only. Overall only 61.2% of the primary tumours retained their original status with respect to both cytosol and nuclear oestrogen receptors on recurrence. These results were influenced by intervening therapy, however, and if only untreated patients are considered, over 70% of their recurrences contain the same combination of cytosol and nuclear receptors as found in the primary tumours. For tumours 'recurring' in the opposite breast, the pattern was similar with 69.2% retaining the same status as the first primary. The agent found most likely to alter I:R status was tamoxifen and in the samples taken from patients undergoing treatment with this drug, no tumour was found to contain measurable receptor.
机译：从总共210名妇女中获得了乳腺癌组织的序贯活检样本，以评估自然发生或由于介入治疗而引起的雌激素受体（ER）状态的任何变化。对所有样品均使用同时测量细胞溶质和核雌激素受体的组合测定法。 155名患者的原发肿瘤活检和后来的局部复发。 26例患者原发肿瘤活检，对侧乳房复发或新发。和29只进行了复发性疾病的连续活检。总体而言，仅61.2％的原发肿瘤在复发时就细胞溶质和核雌激素受体而言都保持了其原始状态。这些结果受到干预疗法的影响，但是，如果仅考虑未经治疗的患者，则超过70％的复发患者具有与原发肿瘤相同的细胞溶质和核受体组合。对于在另一侧乳房中“复发”的肿瘤，该模式相似，其中69.2％的状态与第一例相同。发现最可能改变I：R状态的药物是他莫昔芬，并且在接受该药物治疗的患者的样本中，未发现肿瘤含有可测量的受体。

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