...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British Journal of Cancer >Tumour-associated trypsin inhibitor (TATI) in human ovarian cyst fluid. Comparison with CA 125 and CEA
【24h】

Tumour-associated trypsin inhibitor (TATI) in human ovarian cyst fluid. Comparison with CA 125 and CEA

机译：人卵巢囊肿液中的肿瘤相关胰蛋白酶抑制剂（TATI）。与CA 125和CEA的比较

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The levels of tumour-associated trypsin inhibitor (TATI), CA 125 and CEA were measured in ovarian cyst fluids from 21 patients. TATI in cyst fluid was immunologically and physicochemically similar to the peptide originally isolated from the urine of a patient with ovarian cancer. Mucinous cysts contained significantly higher levels of TATI than did serous cysts. Immunohistochemically TATI was localized in the apical parts of cells of mucinous ovarian cysts. These results suggest that this tumour-associated peptide is actually produced by a tumour. Like TATI, CEA occurred at higher concentrations in mucinous than in serous cyst fluids, whereas CA 125 was found in higher concentrations in serous than in mucinous cyst fluids. The concentrations of these tumours markers in cyst fluids did not correlate with circulating levels of the same markers. In spite of the very high levels of all these tumour markers in benign cyst fluids, serum levels were normal or only slightly elevated. Clearly elevated serum levels occurred only in patients with malignant tumours. Cyst fluid levels of these tumour markers could not be used to distinguish between benign and malignant tumours.
机译：在21名患者的卵巢囊肿液中测量了肿瘤相关胰蛋白酶抑制剂（TATI），CA 125和CEA的水平。囊液中的TATI在免疫学和物理化学上类似于最初从卵巢癌患者尿液中分离出的肽。粘液性囊肿比浆液性囊肿含有显着更高的TATI水平。免疫组织化学TATI定位于粘液性卵巢囊肿细胞的顶端。这些结果表明，该肿瘤相关肽实际上是由肿瘤产生的。像TATI一样，粘液中CEA的浓度高于浆液性囊液，而浆液中的CA 125浓度高于粘液性囊液。这些肿瘤标志物在囊液中的浓度与相同标志物的循环水平不相关。尽管良性囊肿液中所有这些肿瘤标志物的水平很高，但血清水平却是正常的或仅略有升高。血清水平明显升高仅发生于恶性肿瘤患者。这些肿瘤标志物的囊肿液水平不能用于区分良性和恶性肿瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号