Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration

F Crea; L Sun; L Pikor; P Frumento; W L Lam; C D Helgason

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Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration

机译：实体瘤中Polycomb基因的突变分析确定PHC3扩增可能是驱动癌症的遗传改变

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Background:Polycomb group genes (PcGs) are epigenetic effectors implicated in most cancer hallmarks. The mutational status of all PcGs has never been systematically assessed in solid tumours.

机译：背景：多聚群基因（PcGs）是大多数癌症特征中涉及的表观遗传效应子。从未在实体瘤中系统评估所有PcG的突变状态。

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《British Journal of Cancer》 |2013年第6期|共4页
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F Crea; L Sun; L Pikor; P Frumento; W L Lam; C D Helgason;
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中图分类肿瘤学;
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6. Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration [O] . F Crea, L Sun, L Pikor, 2013

机译：实体瘤中Polycomb基因的突变分析确定PHC3扩增可能是驱动癌症的遗传改变
7. Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration. [O] . Crea F., Sun L., Pikor L., 2013

机译：实体瘤中polycomb基因的突变分析将pHC3 +扩增鉴定为可能的癌症驱动遗传改变。
8. Premalignant Genetic and Epigenetic Alterations in Tubal Epithelium from Women with BRCA1 Mutations. [R] . Krumm, A. 2011

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Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration

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