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首页> 外文期刊>Clinical Chemistry: Journal of the American Association for Clinical Chemists >Biochemical Marker Reference Values across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey
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Biochemical Marker Reference Values across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

机译：儿科，成人和老人年龄的生化指标参考值：基于加拿大卫生措施调查建立可靠的儿科和成人参考区间

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BACKGROUND: Biological covariates such as age and sex can markedly influence biochemical marker reference values, but no comprehensive study has examined such changes across pediatric, adult, and geriatric ages. The Canadian Health Measures Survey (CHMS) collected comprehensive nationwide health information and blood samples from children and adults in the household population and, in collaboration with the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER), examined biological changes in biochemical markers from pediatric to geriatric age, establishing a comprehensive reference interval database for routine disease biomarkers.METHODS: The CHMS collected health information, physical measurements, and biosamples (blood and urine) from approximately 12 000 Canadians aged 3–79 years and measured 24 biochemical markers with the Ortho Vitros 5600 FS analyzer or a manual microplate. By use of CLSI C28-A3 guidelines, we determined age- and sex-specific reference intervals, including corresponding 90% CIs, on the basis of specific exclusion criteria.RESULTS: Biochemical marker reference values exhibited dynamic changes from pediatric to geriatric age. Most biochemical markers required some combination of age and/or sex partitioning. Two or more age partitions were required for all analytes except bicarbonate, which remained constant throughout life. Additional sex partitioning was required for most biomarkers, except bicarbonate, total cholesterol, total protein, urine iodine, and potassium.CONCLUSIONS: Understanding the fluctuations in biochemical markers over a wide age range provides important insight into biological processes and facilitates clinical application of biochemical markers to monitor manifestation of various disease states. The CHMS-CALIPER collaboration addresses this important evidence gap and allows the establishment of robust pediatric and adult reference intervals.
机译：背景：诸如年龄和性别之类的生物协变量可以显着影响生化标志物参考值，但是尚无全面的研究检查了儿童，成年和老年年龄的这种变化。加拿大卫生措施调查（CHMS）收集了家庭人口中儿童和成人的全国健康信息和血液样本，并与加拿大儿科参考区间实验室倡议（CALIPER）合作，研究了从儿科到儿童的生化标志物的生物学变化。方法：CHMS收集了大约12000名3-79岁加拿大人的健康信息，身体测量值和生物样本（血液和尿液），并使用Ortho进行了24种生化标记物的测量Vitros 5600 FS分析仪或手动微孔板。通过使用CLSI C28-A3指南，我们根据特定的排除标准确定了针对年龄和性别的参考区间，包括相应的90％CI。结果：生化标志物参考值呈现出从儿科到老年的动态变化。大多数生化标志物需要年龄和/或性别划分的某种组合。除碳酸氢盐外，所有分析物都需要两个或更多个年龄分区，而碳酸氢盐在整个生命周期中保持不变。除碳酸氢盐，总胆固醇，总蛋白，尿碘和钾外，大多数生物标志物还需要进行其他性别划分。监视各种疾病状态的表现。 CHMS-CALIPER合作解决了这一重要的证据空白，并允许建立可靠的儿科和成人参考区间。

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