...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Critical care : >Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients
【24h】

Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients

机译：临床评论：中性粒细胞明胶酶相关脂质运载蛋白对重症监护患者急性肾损伤的预测价值

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neutrophil gelatinase-associated lipocalin (NGAL) may be an early marker of acute kidney injury (AKI), but elevated NGAL occurs in a wide range of systemic diseases. Because intensive care patients have high levels of comorbidity, our objective was to conduct a systematic review of the literature to evaluate the value of plasma and urinary NGAL to predict AKI in these patients. We conducted a systematic electronic literature search of MEDLINE through PubMed, EMBASE, and Cochrane Library for all English language research publications evaluating the predictive value of plasma or urinary NGAL (or both) for AKI in adult intensive care patients. Two authors independently extracted data by using a standardized extraction sheet including study characteristics, type of NGAL measurements, and type of outcome measures. The primary summary measure was area under receiver operating characteristic curve (AuROC) for NGAL to predict study outcomes. Eleven studies with a total of 2,875 (range of 20 to 632) participants were included: seven studies assessed urinary NGAL and six assessed plasma NGAL. The included studies varied in design, including observation period from NGAL sampling to AKI follow-up (range of 12 hours to 7 days), definition of baseline creatinine value, and urinary NGAL quantification method (normalizing to urinary creatinine or absolute concentration). AuROC values for the prediction of AKI ranged from 0.54 to 0.98. Five studies reported AuROC for use of renal replacement therapy ranging from 0.73 to 0.89, and four studies reported AuROC for mortality ranging from 0.58 to 0.83. There were no differences in the predictive values of urinary and plasma NGAL. The heterogeneity in study design and results made it difficult to evaluate the value of NGAL to predict AKI in intensive care patients. NGAL seems to have reasonable value in predicting use of renal replacement therapy but not mortality.
机译：中性粒细胞明胶酶相关的脂蛋白（NGAL）可能是急性肾损伤（AKI）的早期标志物，但NGAL升高在多种全身性疾病中均会发生。由于重症监护患者的合并症水平很高，因此我们的目标是对文献进行系统的回顾，以评估血浆和尿液NGAL的价值以预测这些患者的AKI。我们通过PubMed，EMBASE和Cochrane图书馆对MEDLINE进行了系统的电子文献搜索，以评估所有英语研究出版物，评估血浆或尿液NGAL（或两者）对成人重症监护患者的AKI的预测价值。两位作者使用标准化的提取表独立提取数据，包括研究特征，NGAL测量类型和结果测量类型。主要的汇总指标是NGAL接收器工作特征曲线（AuROC）下的面积，以预测研究结果。包括11项研究，共有2875名受试者（范围从20到632名）：七项研究评估了尿NGAL，六项评估了血浆NGAL。纳入研究的设计各不相同，包括从NGAL采样到AKI随访（12小时至7天）的观察期，基线肌酐值的定义以及尿NGAL定量方法（标准化为尿肌酐或绝对浓度）。预测AKI的AuROC值介于0.54至0.98之间。五项研究报告了AuROC用于肾脏替代治疗的范围从0.73至0.89，四项研究报告了AuROC用于死亡率的范围从0.58至0.83。尿和血浆NGAL的预测值无差异。研究设计和结果的异质性使得难以评估NGAL预测重症监护患者AKI的价值。 NGAL在预测肾脏替代疗法的使用方面似乎具有合理的价值，但对死亡率没有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号