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Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)

机译:急性肾损伤的诊断,评估和处理:KDIGO摘要(第1部分)

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Acute kidney injury (AKI) is a common and serious problem affecting millions and causing death and disability for many. In 2012, Kidney Disease: Improving Global Outcomes completed the first ever, international, multidisciplinary, clinical practice guideline for AKI. The guideline is based on evidence review and appraisal, and covers AKI definition, risk assessment, evaluation, prevention, and treatment. In this review we summarize key aspects of the guideline including definition and staging of AKI, as well as evaluation and nondialytic management. Contrast-induced AKI and management of renal replacement therapy will be addressed in a separate review. Treatment recommendations are based on systematic reviews of relevant trials. Appraisal of the quality of the evidence and the strength of recommendations followed the Grading of Recommendations Assessment, Development and Evaluation approach. Limitations of the evidence are discussed and a detailed rationale for each recommendation is provided.
机译:急性肾损伤(AKI)是一个普遍且严重的问题,影响数百万人,并导致许多人死亡和致残。 2012年,《肾脏病:改善全球结局》完成了AKI的第一个国际,多学科临床实践指南。该指南基于证据审查和评估,涵盖AKI定义,风险评估,评估,预防和治疗。在这篇综述中,我们总结了指南的关键方面,包括AKI的定义和阶段以及评估和非透析管理。对比诱发的AKI和肾脏替代治疗的管理将在单独的评论中讨论。治疗建议基于对相关试验的系统评价。对证据质量和建议强度的评估遵循建议书评估,制定和评估方法的分级。讨论了证据的局限性,并提供了每个建议的详细理由。

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