Cephaloglycin and Its Biologically Active Metabolite Desacetylcephaloglycin

W. E. Wick; W. E. Wright; H. V. Kuder

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Cephaloglycin and Its Biologically Active Metabolite Desacetylcephaloglycin

机译：头霉素及其生物活性代谢产物去乙酰头孢菌素

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Chromatographic studies and microbiological assays show that, after oral administration, cephaloglycin is partially converted in man to a biologically active metabolite desacetylcephaloglycin. The antibacterial activity of this metabolite compared to that of cephaloglycin is equivalent against gram-positive organisms but is lower against gram-negative bacilli. Successful therapy of urinary tract infections with cephaloglycin must be mainly attributed to the antibacterial activity of this metabolite. At the present time, it is not possible to assess what influence low amounts of unaltered cephaloglycin have on the outcome of therapy.

机译：色谱研究和微生物学分析表明，口服后，头甘氨酸在人体内被部分转化为具有生物活性的代谢产物去乙酰头孢甘菊糖。与头孢菌素相比，这种代谢产物的抗菌活性与革兰氏阳性生物等效，但对革兰氏阴性细菌却较低。用头孢菌素成功治疗尿路感染必须主要归因于这种代谢产物的抗菌活性。目前，尚无法评估少量未改变的头孢糖苷对治疗结果的影响。

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《Applied Microbiology》 |1971年第3期|共9页
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W. E. Wick; W. E. Wright; H. V. Kuder;
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中图分类微生物学;
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1. Method for the Detection and Quantitative Assay of Cephaloglycin and Its Biologically Active Metabolites [J] . Marvin M. Hoehn, Charles T. Pugh Applied Microbiology . 1968,第8期

机译：头霉素及其生物活性代谢产物的检测和定量分析方法
2. CYP27A1 acts on the pre-vitamin D3 photoproduct, biologically active hydroxy-metabolites lumisterol, producing biologically active hydroxy-metabolites [J] . Tuckey Robert C., Li Wei, Ma Dejian, The Journal of Steroid Biochemistry and Molecular Biology . 2018,第期

机译：CYP27A1作用于维生素D3光调节，生物活性羟基 - 代谢物氟玻璃，生产生物活性羟基代谢物
3. Environmental metabolites of fluoroquinolones: synthesis, fractionation and toxicological assessment of some biologically active metabolites of ciprofloxacin [J] . Gareth Lewis, Albert Juhasz, Euan Smith Environmental Science and Pollution Research . 2012,第7期

机译：氟喹诺酮类的环境代谢物：环丙沙星某些生物活性代谢物的合成，分级分离和毒理学评估
4. Application of Diels-Alder Derivatization with 4-Substituted 1,2,4-Triazole-3,5-Diones for Analysis of Vitamin D Metabolites and Other Biologically Active Conjugated Dienes Using LC-ESI-MS/MS [C] . Pavel A Aronov, Katrin Georgi, Sung Hee Hwang, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：用4-取代的1,2,4-三唑-3,5-二酮衍生化Diels-Alder衍生化用于使用LC-ESI-MS / MS分析维生素D代谢物和其他生物活性共轭二烯的分析
5. Extraction and Purification of Biologically Active Metabolites from Rhodococcus sp. MTM3W5.2 [D] . Alenazi, Mohrah Ali. 2018

机译：rhodococcus sp的生物活性代谢物的提取和纯化。 MTM3W5.2.
6. Cephaloglycin and Its Biologically Active Metabolite Desacetylcephaloglycin [O] . W. E. Wick, W. E. Wright, H. V. Kuder 1971

机译：头霉素及其生物活性代谢产物去乙酰头孢菌素
7. PROBLEMS IN THE BIO-ASSAY OF ORALLY ADMINISTERED CEPHALOGLYCIN IN BIOLOGICAL FLUIDS AND METHOD FOR THE DETECTION OF ITS METABOLITE, DESACETYLCEPHALOGLYCIN [O] . KIHACHIRO SHIMIZU, HARUO NISHIMURA 1970

机译：在生物流体中口服施用头孢菌素的生物检测中的问题及其代谢物检测，Desacetylcephalogly

Cephaloglycin and Its Biologically Active Metabolite Desacetylcephaloglycin

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