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Fermentation Studies with Streptomyces griseus II. Synthetic Media for the Production of Streptomycin

机译：灰链霉菌的发酵研究II。生产链霉素的合成培养基

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Synthetic media for streptomycin fermentation were studied to determine which media gave highest yields of streptomycin. The effect of salts on streptomycin production by Streptomyces griseus was examined, and a suitable combination of salts was established in a glucose-casein medium. This medium yielded 3,000 μg/ml of the antibiotic with an inoculum of 1.6%. Substitution of amino acids for casein was examined. Of 17 amino acids tested, best results were obtaind with sodium aspartate. Substitution of ammonium salts was tried, and an excellent streptomycin yield was obtained with a medium containing ammonium citrate.
机译：对链霉素发酵的合成培养基进行了研究，以确定哪种培养基产生链霉素的产量最高。检查了盐对灰霉链霉菌产生链霉素的影响，并在葡萄糖-酪蛋白培养基中建立了盐的合适组合。该培养基产生了3,000μg/ ml的抗生素，接种量为1.6％。检查了酪蛋白的氨基酸取代。在测试的17种氨基酸中，天冬氨酸钠获得了最佳结果。尝试了铵盐的替代，并用含有柠檬酸铵的培养基获得了优异的链霉素收率。

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