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首页> 外文期刊>Applied Microbiology >Antimicrobial Activity of Several Bis-Methanethiolsulfonates
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Antimicrobial Activity of Several Bis-Methanethiolsulfonates

机译：几种双甲硫基磺酸盐的抗菌活性

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We determined the inhibitory end point of a series of bis-methanethiolsulfonates, CH3SO2S(CH2)nSSO2CH3 (n = 2 to 6), and correlated the structures with antimicrobial activity. Eleven microorganisms were used in the evaluation, and the maximal activity occurred when the methylene chain length was five or six. The effect of CH3SO2S(CH2)5SSO2CH3 (PMTS) on respiration of Aerobacter aerogenes and Staphylococcus aureus was studied at various stages of their growth cycles. The effect on viability was correlated with that of respiration in the case of A. aerogenes. Respiratory inhibition caused by PMTS varied with the growth phase of both organisms, being most pronounced when the cells tested were taken during the period of transition from the log to stationary phase. The lethal effect on A. aerogenes was also greatest at this time. During the period of increased sensitivity, the antimicrobial activity of PMTS appears to be closely related to cell respiration. The delayed rate of kill otherwise observed may reflect an impairment of protein metabolism through reaction with sensitive SH groups.
机译：我们确定了一系列双甲硫基磺酸盐，CH3SO2S（CH2）nSSO2CH3（n = 2至6）的抑制终点，并将结构与抗菌活性相关联。在评估中使用了11种微生物，当亚甲基链长为5或6时，活性最大。研究了CH3SO2S（CH2）5SSO2CH3（PMTS）在产气杆菌和金黄色葡萄球菌生长周期各个阶段对呼吸作用的影响。在产气曲霉的情况下，对生存力的影响与呼吸的影响相关。由PMTS引起的呼吸抑制作用随两种生物体的生长期而变化，在从对数期到静止期的过渡期内采集受试细胞时，这种现象最为明显。此时，对产气农杆菌的致死作用也最大。在敏感性增加期间，PMTS的抗菌活性似乎与细胞呼吸密切相关。否则观察到的延迟的杀灭速率可能反映了通过与敏感的SH基团反应而损害了蛋白质代谢。

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