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首页> 外文期刊>Applied Microbiology >Degradation of Methoxylated Benzoic Acids by a Nocardia from a Lignin-Rich Environment: Significance to Lignin Degradation and Effect of Chloro Substituents
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Degradation of Methoxylated Benzoic Acids by a Nocardia from a Lignin-Rich Environment: Significance to Lignin Degradation and Effect of Chloro Substituents

机译：富木质素环境中的诺卡氏菌对甲氧基化苯甲酸的降解：对木质素降解和氯代化合物的影响的意义

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摘要

Strain A81 of Nocardia corallina hydroxylates or demethylates p-anisic acid to p-hydroxybenzoic acid and isovanillic acid. It demethylates veratric acid to a mixture of vanillic and isovanillic acids. These are both demethylated to protocatechuic acid, which undergoes ring cleavage to afford β-carboxy-cis-cis-muconic acid. The intermediacy of protocatechuic acid in the catabolic pathway of veratric acid was confirmed by blocking ring cleavage with an additional substituent in the ring: 5-chlorovanillic acid was demethylated to 5-chloro-protocatechuic acid, which accumulated. Chloro substituents in the ring of other methoxylated benzoic acids also arrested their normal metabolism by the Nocardia: an ortho-chloro substituent thwarted both demethylation and ring-opening. ortho-Hydroxylation of p-methoxybenzoic acid to isovanillic acid was unaffected by a chlorine ortho to the methoxyl group. Washed whole cells of veratric acid-grown N. corallina A81 produced no detected structural changes in an isolated lignin. The implications of this observation are discussed.
机译：诺卡氏菌诺卡氏菌的菌株A81将对茴香酸羟基化或去甲基化为对羟基苯甲酸和异香草酸。它将维甲酸去甲基化为香草酸和异香草酸的混合物。它们都被去甲基化为原儿茶酸，其经过环裂解以提供β-羧基-顺-顺-粘康酸。通过用环中的另外一个取代基阻断环裂解，从而证实了原儿茶酸在维甲酸分解代谢途径中的中间作用：5-氯香草酸被脱甲基成5-氯-原儿茶酸，从而积累了该物质。其他甲氧基化苯甲酸环中的氯取代基也被诺卡氏菌阻止了其正常代谢：邻氯取代基阻碍了脱甲基和开环。对甲氧基苯甲酸的邻羟基羟基化为异香草酸不受甲氧基邻位氯的影响。洗涤过的维甲酸生长的N.corallina A81的全细胞在分离的木质素中未检测到结构变化。讨论了这种观察的含义。

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