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首页> 外文期刊>Applied and Environmental Microbiology >Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation
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Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation

机译：猪链球菌所有血清型荚膜多糖合成基因簇的遗传分析：产生荚膜变异的潜在机制。

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Streptococcus suis strains are classified into 35 serotypes on the basis of the antigenicity of their capsular polysaccharides (CPs). CP synthesis genes are known to be clustered on the chromosome (cps gene cluster). The entire cps gene clusters of S. suis have so far been sequenced in 15 serotypes and found to be located between orfZ and aroA. In this study, to provide comprehensive information about S. suis CPs, we sequenced the entire cps gene clusters of the remaining serotypes and analyzed the complete set of S. suis cps gene clusters. Among the 35 cps gene clusters, 22 were located between orfZ and aroA, whereas the other 13 were flanked by other gene(s) on the chromosomes, and the chromosomal locus was classified into five patterns. By clustering analysis, the predicted products of cps genes found in the 35 serotypes were assigned into 291 homology groups, and all serotypes possessed a serotype-specific gene, except for serotypes 1, 2, 1/2, and 14. Because of the presence of genes encoding flippase (wzx) and polymerase (wzy), CPs of all serotypes were thought to be synthesized by the Wzx/Wzy pathway. Our data also implied the possibility of the transfer of the entire or partial cps gene clusters among S. suis strains, as well as the influence of spontaneous mutations in a single gene or a few genes on the antigenicity of some serotypes. Accumulation of these gene transfers and small-scale mutations may have generated the antigenic diversity of S. suis CPs.
机译：猪链球菌菌株根据其荚膜多糖（CPs）的抗原性分为35种血清型。已知CP合成基因聚集在染色体上（ cps 基因簇）。到目前为止，猪链球菌的所有 cps 基因簇已被测序为15种血清型，并位于 orfZ 和 aroA 之间。在这项研究中，为了提供有关猪链球菌CP的全面信息，我们对其余血清型的整个 cps 基因簇进行了测序，并分析了猪链球菌 cps 的完整基因组。集群。在35个 cps 基因簇中，有22个位于 orfZ 和 aroA 之间，而另外13个位于其他基因的侧翼。染色体和染色体位点分为五个模式。通过聚类分析，将在35种血清型中发现的 cps 基因的预测产物分配到291个同源组中，所有血清型均具有血清型特异性基因，除了血清型1、2、1 / 2， 14.由于存在编码翻转酶（ wzx ）和聚合酶（ wzy ）的基因，所有血清型的CP被认为是通过Wzx / Wzy途径合成的。我们的数据还暗示了猪链球菌菌株中全部或部分 cps 基因簇转移的可能性，以及单个基因或几个基因的自发突变对猪链球菌抗原性的影响。一些血清型。这些基因转移和小规模突变的积累可能已经产生了猪链球菌CP的抗原多样性。

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