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Metabolism of Sialic Acid by Bifidobacterium breve UCC2003

机译:短双歧杆菌UCC2003对唾液酸的代谢

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Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin- and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3′-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010.
机译:双歧杆菌是居住在人类和其他哺乳动物胃肠道中的特定的共生细菌群。短双歧杆菌UCC2003先前已被证明利用了几种植物来源的碳水化合物,包括纤维糊精,淀粉和半乳聚糖。在本研究中,我们调查了此菌株利用粘蛋白和人乳寡糖(HMO)衍生的碳水化合物唾液酸的能力。使用转录组学和功能基因组学方法的结合,我们确定了一个致力于唾液酸吸收和代谢的基因簇。此外,我们证明短双歧杆菌UCC2003可以交叉饲喂另一种婴儿肠道双歧杆菌菌株双歧双歧杆菌PRL2010代谢的3'-唾液乳糖(一种丰富的HMO)的唾液酸。

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