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首页> 外文期刊>Applied Microbiology >Potential Fate of Ingested Lactobacillus plantarum and Its Occurrence in Human Feces
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Potential Fate of Ingested Lactobacillus plantarum and Its Occurrence in Human Feces

机译：摄入植物乳杆菌的潜在命运及其在人粪便中的发生

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Lactobacillus plantarum has been used in human clinical trials to promote beneficial effects in the immune system, to alleviate intestinal disorders, and to reduce the risk of cardiovascular disease. It is also involved in many fermentation processes in the food industry. However, information on the fate of ingested L. plantarum is limited. In this study, 61 subjects received daily doses of fermented milk containing 2 × 10~(11) cells of L. plantarum Lp115 for different periods of time. The target microorganism was monitored in the fecal microbiota via quantitative PCR (qPCR). L. plantarum was detected and quantified in all of the subjects during the ingestion periods. The differences between the L. plantarum levels at time zero and during all the different ingestion periods were statistically significant ( P = 0.001). However, at 15 and 45 days after discontinuing supplementation, the number of lactobacilli was reduced to the baseline level (those at time zero). A longer period with L. plantarum in the diet did not result in increased levels of this bacterium in the stool, based on postconsumption evaluations ( P = 0.001). The qPCR method was specific and sensitive for L. plantarum quantification in such a complex microbial environment as the gastrointestinal tract.
机译：植物乳杆菌已经在人类临床试验中用于促进免疫系统的有益作用，减轻肠道疾病并降低心血管疾病的风险。它也参与食品工业中的许多发酵过程。但是，有关摄入的植物乳杆菌命运的信息有限。在这项研究中，有61名受试者在不同的时间每天接受含有2×10〜（11）细胞的植物乳杆菌Lp115的发酵乳剂量。通过定量PCR（qPCR）在粪便菌群中监测目标微生物。在摄取期间，在所有受试者中检测到了植物乳杆菌并对其进行了定量。在零时点和所有不同的摄入期间，植物乳杆菌水平之间的差异具有统计学意义（P = 0.001）。但是，在停药后第15天和第45天，乳杆菌的数量减少到基线水平（零时数）。根据食用后评估，长期食用植物乳杆菌不会导致粪便中这种细菌水平升高（P = 0.001）。在复杂的微生物环境（如胃肠道）中，qPCR方法对植物乳杆菌定量具有特异性和敏感性。

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