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Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

机译:双歧杆菌双歧杆菌PRL2010调节宿主固有免疫反应。

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Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-κB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.
机译:在这里,我们描述了从人类细胞系和小鼠模型肠道细胞在双歧双歧杆菌PRL2010分别暴露和定殖后的转录组分析中获得的数据。在已知与先天免疫有关的基因的转录中检测到显着变化。此外,酶联免疫吸附测定(ELISA)的结果表明,暴露于双歧双歧杆菌PRL2010可能导致白介素6(IL-6)和IL-8细胞因子的产生增加,大概是通过NF-κB激活引起的。获得的全局转录图谱强烈表明双歧双歧杆菌PRL2010调节宿主的先天免疫应答。

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