Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies

J. Holmgren; ?. Andersson; G. Wallerstrom; ?. Ouchterlony

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Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies

机译：霍乱免疫的实验研究II。血清抗体和局部抗体介导的保护性抗毒性免疫的证据

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By use of the ileal loop technique, the resistance to challenge with cholera enterotoxin was compared between unimmunized rabbits and rabbits immunized with toxin or toxoids. It was shown that subcutaneous as well as intraintestinal immunization induced protective immunity, the toxin being a better immunogen than Formalin-induced toxoid and much better than heat-induced toxoid. The relation between protection and serum antitoxin titer was poor, e.g., protection was seen in the absence of demonstrable serum antibodies. However, intravenous administration of antitoxic antiserum conferred some protection, suggesting that local as well as serum-mediated antitoxic immunity is operating in the host defence against cholera.

机译：通过回肠环技术，在未免疫的兔子和经毒素或类毒素免疫的兔子之间比较了霍乱肠毒素对挑战的抵抗力。结果表明，皮下和肠内免疫均能产生保护性免疫力，该毒素的免疫原性优于福尔马林诱导的类毒素，且远胜于热诱导的类毒素。保护作用与血清抗毒素滴度之间的关系很差，例如，在没有可证明的血清抗体的情况下可以看到保护作用。但是，静脉内给予抗毒性抗血清可提供一定的保护作用，这表明局部和血清介导的抗毒性免疫在抵抗霍乱的宿主防御中起作用。

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《Infection and immunity》 |1972年第5期|共6页
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J. Holmgren; ?. Andersson; G. Wallerstrom; ?. Ouchterlony;
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中图分类医学免疫学;
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1. Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies [J] . J. Holmgren, ?. Andersson, G. Wallerstrom, Infection and immunity . 1972,第5期

机译：霍乱免疫的实验研究II。血清抗体和局部抗体介导的保护性抗毒性免疫的证据
2. Antitoxic immunity in experimental cholera: protection, and serum and local antibody responses in rabbits after enteral and parenteral immunization. [J] . J Holmgren, A M Svennerholm, O Ouchterlony, Infection and immunity . 1975,第6期

机译：实验性霍乱的抗毒性免疫：肠内和肠胃外免疫后的保护作用以及兔血清和局部抗体反应。
3. Mechanism of Action of Intestinal Antibody in Experimental Cholera II. Antibody-Mediated Antibacterial Reaction at the Mucosal Surface [J] . Rolf Freter Infection and immunity . 1970,第5期

机译：肠道抗体在实验霍乱中的作用机理粘膜表面的抗体介导的抗菌反应
4. ORAL IMMUNIZATION WITH ACTINOBACILLUS PLEUROPNEUMONIAE ANTIGENS IN ENTEROCOATED MICROSPHERES INDUCE SERUM AND MUCOSAL ANTIBODIES [C] . C.W. Liao, I.C. Cheng, K.S. Yeh, Congress of the International Pig Veterinary Society . 2000

机译：肠溶微球中的Actinobacillus胸膜炎抗原口服免疫诱导血清和粘膜抗体
5. Part I. A small-molecule library strategy for disruption of protein-protein interactions. Part II. Antibody-catalyzed anaerobic destruction of methamphetamine: A new direction in immunopharmacotherapy. Part III. Design and synthesis of reactive immunization haptens. [D] . Xu, Yang. 2007

机译：第一部分。破坏蛋白质间相互作用的小分子文库策略。第二部分甲基苯丙胺的抗体催化厌氧破坏：免疫药物治疗的新方向。第三部分反应性免疫半抗原的设计与合成。
6. Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies [O] . J. Holmgren, Å. Andersson, G. Wallerstrom, 1972

机译：霍乱免疫的实验研究II。血清抗体和局部抗体介导的保护性抗毒性免疫的证据
7. Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies [O] . J. Holmgren, Å. Andersson, G. Wallerstrom, 1972

机译：霍乱免疫II的实验研究。血清抗体介导的保护抗毒性免疫以及局部抗体的证据
8. Humoral Immunity in Experimental Syphilis. I. The Demonstration of Resistance Conferred by Passive Immunization. II. The Relationship of Neutralizing Factors in Immune Serum to Acquired Resistance. [R] . Bishop, N. H., Miller, J. N. 1975

机译：实验性梅毒的体液免疫。一，被动免疫引起的抗药性证明。 II。免疫血清中和因子与获得性耐药的关系。

Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies

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