• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Antitoxic immunity in experimental cholera: protection, and serum and local antibody responses in rabbits after enteral and parenteral immunization.
【24h】

Antitoxic immunity in experimental cholera: protection, and serum and local antibody responses in rabbits after enteral and parenteral immunization.

机译：实验性霍乱的抗毒性免疫：肠内和肠胃外免疫后的保护作用以及兔血清和局部抗体反应。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The protective effect of enternal and parenteral immunization with cholera toxin antigen against experimental cholera in rabbits was studied by using the small-bowel loop technique. Subcutaneous injection of crude toxin as well as purified toxin or toxoids gave rise to significant protection against toxin challenge. The enhanced resistance to toxin was found to correspond to a many-fold higher magnitude of protection against challenge with live vibrios. In the primary response the protection increased during the first month. Booster immunization gave rise to a further increased immunity which, however, declined rapidly. Multiple oral or repeated intraintestinal antigen administrations also induced protective antitoxic immunity although of less magnitude than that obtained by parenteral immunization. Enteral and, to a lesser extent, parenteral immunization gave rise to increased antitoxic antibody titers and immunoglobulin levels in intestinal washings and mucosa scraping. Immunoglobulin G (IgG) and IgG antitoxins predominated, but after enteral immunization total IgA and specific IgA antibodies occasionally reached levels similar to those for IgG. In serum, significantly increased antibody levels (IgG) were only recorded after parenteral immunization. Both the primary binding and the neutralizing antitoxin titers showed a stayistically significant correlation with the degree of protection against toxin challenge; however, for the neutralizing antibodies this correlation was not without exceptions. No relation to protection was found for intestinal antibodies. The results of the present study indicate that enternal as well as parenteral immunization with toxin antigen can give rise to effective cholera immunity. After enternal immunization, the protection appears to be medicated by locally synthesized antibodies. After parenteral vaccination both serum-derived and locally produced antibodies seem to be effective.
机译：利用小肠loop技术研究了霍乱毒素抗原肠内和肠胃外免疫对实验性霍乱的保护作用。皮下注射粗毒素以及纯化的毒素或类毒素产生了针对毒素挑战的显着保护作用。发现对毒素的增强抵抗力对应于抵抗活弧菌攻击的更高数量级的保护。在第一反应中，保护在第一个月有所增加。加强免疫使免疫力进一步提高，但是迅速下降。多次口服或重复肠道内抗原施用也诱导了保护性抗毒性免疫，尽管其程度小于通过肠胃外免疫获得的抗毒性。肠内和肠外免疫（在较小程度上）在肠道冲洗液和粘膜刮擦中增加了抗毒性抗体滴度和免疫球蛋白水平。免疫球蛋白G（IgG）和IgG抗毒素占主导地位，但在肠内免疫后，总IgA和特异性IgA抗体有时达到与IgG相似的水平。在血清中，仅在肠胃外免疫后才记录到抗体水平（IgG）明显升高。初级结合力和中和性抗毒素效价均显示出与抗毒素攻击的防护程度保持显着的相关性。但是，对于中和抗体，这种相关性并非没有例外。没有发现与肠道抗体的保护有关。本研究的结果表明，肠毒素和肠胃外毒素毒素免疫可以产生有效的霍乱免疫力。肠内免疫后，该保护作用似乎是通过局部合成的抗体来进行的。肠胃外疫苗接种后，血清和本地产生的抗体似乎都是有效的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号