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首页> 外文期刊>Infection and immunity >Effect of glucocorticosteroids on the phagocytosis and intracellular killing by peritoneal macrophages.
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Effect of glucocorticosteroids on the phagocytosis and intracellular killing by peritoneal macrophages.

机译：糖皮质激素对腹膜巨噬细胞吞噬作用和细胞内杀伤的影响。

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The effect of hydrocortisone on the phagocytosis and intracellular killing by mouse peritoneal macrophages in vitro was studied by a method making it possible to measure these processes separately. The results showed that in vivo treatment with 15 mg of hydrocortisone acetate did not significantly decrease the phagocytosis of several bacterial species such as Staphylococcus albus, Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa. The killing indexes of normal macrophages for the various microorganisms were found to be significantly different. This may indicate that the bactericidal mechanisms are not uniform for these bacteria. The effect of hydrocortisone on the intracellular killing was also variable. For Staphylococcus albus a normal killing index was found. For the other species of bacterial and for Candida albicans some decrease was found, but this was only significant for Salmonella typhimurium. It is concluded that a decrease host resistance due to glucocorticosterioid treatment is not caused by a direct effect of these drugs on the phagocytosis and intracellular killing by mononuclear phagocytes.
机译：研究了氢化可的松对小鼠吞噬巨噬细胞的吞噬作用和细胞内杀伤作用的影响，方法是通过一种可以单独测量这些过程的方法来进行的。结果表明，用15 mg醋酸氢化可的松进行体内处理不会显着降低几种细菌种类（如白葡萄球菌，金黄色葡萄球菌，大肠杆菌，鼠伤寒沙门氏菌和铜绿假单胞菌）的吞噬作用。发现正常巨噬细胞对各种微生物的杀灭指数明显不同。这可能表明这些细菌的杀菌机理不统一。氢化可的松对细胞内杀伤的作用也是可变的。对于白葡萄球菌，发现正常的杀灭指数。对于其他种类的细菌和白色念珠菌，有所减少，但这仅对鼠伤寒沙门氏菌有意义。结论是，糖皮质激素治疗引起的宿主抗性降低不是由这些药物对吞噬作用和单核吞噬细胞杀伤细胞内的直接作用引起的。

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